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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Rattanawong, Kasidit Kerdsomboon, Kittikhun Auesukaree, Choowong |
Description | Country affiliation: Thailand Author Affiliation: Rattanawong K ( Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand); Kerdsomboon K ( Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand); Auesukaree C ( Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand) |
Abstract | Alachlor is a widely used pre-emergent chloroacetanilide herbicide which has been shown to have many harmful ecological and environmental effects. However, the mechanism of alachlor-induced oxidative stress is poorly understood. We found that, in Saccharomyces cerevisiae, the intracellular levels of reactive oxygen species (ROS) including superoxide anions were increased only after long-term exposure to alachlor, suggesting that alachlor is not a pro-oxidant. It is likely that alachlor-induced oxidative stress may result from protein denaturation because alachlor rapidly induced an increased protein aggregation, leading to upregulation of SSA4 and HSP82 genes encoding heat shock proteins (Hsp) of Hsp70 and Hsp90 family, respectively. Although only SOD1 encoding Cu/Zn-superoxide dismutase (SOD), but not SOD2 encoding Mn-SOD, is essential for alachlor tolerance, both SODs play a crucial role in reducing alachlor-induced ROS. We found that, after alachlor exposure, glutathione production was inhibited while its utilization was increased, suggesting the role of glutathione in protecting cells against alachlor, which becomes more important when lacking Cu/Zn-SOD. Based on our results, it seems that alachlor primarily causes damages to cellular macromolecules such as proteins, leading to an induction of endogenous oxidative stress, of which intracellular antioxidant defense systems are required for elimination. |
File Format | HTM / HTML |
ISSN | 08915849 |
Volume Number | 89 |
e-ISSN | 18734596 |
Journal | Free Radical Biology and Medicine |
Language | English |
Publisher | Elsevier |
Publisher Date | 2015-12-01 |
Publisher Place | United States |
Access Restriction | Subscribed |
Subject Keyword | Discipline Free radicals biology Acetamides Pharmacology Glutathione Metabolism Herbicides Oxidative Stress Drug Effects Saccharomyces Cerevisiae Superoxide Dismutase Blotting, Western Heat-shock Proteins Genetics Oxidation-reduction Protein Denaturation Rna, Messenger Reactive Oxygen Species Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Growth & Development Journal Article Research Support, Non-u.s. Gov't |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Eukaryota Inorganic Chemicals Organic Chemicals Enzymes and Coenzymes Amino Acids, Peptides, and Proteins Nucleic Acids, Nucleotides, and Nucleosides Chemical Actions and Uses Investigative Techniques Chemical Phenomena Metabolism |
Subject | Biochemistry Physiology (medical) |
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