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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Chen, Yi-Ren Chang, Kai-Ting Tsai, May-Jywan Lee, Chia-Hung Huang, Kao-Jean Cheng, Henrich Ho, Yen-Peng Chen, Jian-Chyi Yang, Hsueh-Hui Weng, Ching-Feng |
Description | Country affiliation: Taiwan Author Affiliation: Chen YR ( Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.); Chang KT ( Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.); Tsai MJ ( Neural Regeneration Laboratory, Neurological Institute, Taipei Veterans General Hospital, Taipei 112, Taiwan.); Lee CH ( Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.); Huang KJ ( Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.); Cheng H ( Neural Regeneration Laboratory, Neurological Institute, Taipei Veterans General Hospital, Taipei 112, Taiwan.); Ho YP ( Department of Chemistry, National Dong Hwa University, Hualien 974, Taiwan.); Chen JC ( Department of Biotechnology, Southern Taiwan University, Tainan 710, Taiwan.); Yang HH ( Department of Research, Buddhist Tzu Chi General Hospital, General Education Center, Tzu Chi College of Technology, Hualien 970, Taiwan.); Weng CF ( Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan. Electronic address: cfweng@mail.ndhu.edu.tw.) |
Abstract | The direct modulation of Antrodia cinnamomea (AC) on the prominent role of liver fibrosis-hepatic stellate cells (HSCs) in situ remains unclear. Firstly, the administration of A. cinnamomea mycelial extract (ACME) could improve liver morphology and histological changes including collagen formation and GPT activity in the liver of thioacetamide (TAA)-injured rats. The morphology and fatty acid restore of TAA-induced HSCs (THSCs) returned to the non-chemical induced HSCs (NHSCs) type as measured by immunofluorescence and Oil Red O staining. PPARγ was upregulated associated with the lowering of -SMA protein in NHSC-ACME. ACME inhibited the MMP-2 activity in NHSCs by gelatin Zymography. After LC-MS/MS, the cytoskeleton (tubulin, lamin A) and heat shock protein 8 in NHSC-ACME, and guanylate kinase, brain-specific kinase, SG-II and p55 proteins were downregulated in THSC-ACME. Whereas MHC class II, SMC6 protein, and phospholipase D were upregulated in NHSC-ACME. Furthermore, PKG-1 was downregulated in NHSC-ACME and upregulated in THSC-ACME. SG-II and p55 proteins were downregulated in NHSC-ACME and THSC-ACME by Western blotting. Taken together, the beneficial effect of A. cinnamomea on the induction of HSC cellular proteins is potentially applied as an alternative and complementary medicine for the prevention and amelioration of a liver injury. |
File Format | HTM / HTML |
ISSN | 02786915 |
Volume Number | 69 |
e-ISSN | 18736351 |
Journal | Food and Chemical Toxicology |
Language | English |
Publisher | Elsevier |
Publisher Date | 2014-07-01 |
Publisher Place | Great Britain (UK) |
Access Restriction | Subscribed |
Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Antrodia Chemistry Hepatic Stellate Cells Drug Effects Plant Extracts Pharmacology Actins Metabolism Animals Biological Markers Cell Survival Fatty Acids Functional Food Male Matrix Metalloproteinase 2 Matrix Metalloproteinase Inhibitors Ppar Gamma Rats, Sprague-dawley Thioacetamide Toxicity Journal Article Research Support, Non-u.s. Gov't |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Cells Eukaryota Organic Chemicals Macromolecular Substances Enzymes and Coenzymes Lipids Amino Acids, Peptides, and Proteins Complex Mixtures Chemical Actions and Uses Cell Physiological Phenomena Physiological Phenomena |
Subject | Toxicology Food Science Medicine |
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