NDLI: Temporal Unmixing of Dynamic Fluorescent Images by Blind Source Separation Method with a Convex Framework

Content Provider	PubMed Central
Author	Chen, Duofang Liang, Jimin Guo, Kui
Copyright Year	2015
Abstract	By recording a time series of tomographic images, dynamic fluorescence molecular tomography (FMT) allows exploring perfusion, biodistribution, and pharmacokinetics of labeled substances in vivo. Usually, dynamic tomographic images are first reconstructed frame by frame, and then unmixing based on principle component analysis (PCA) or independent component analysis (ICA) is performed to detect and visualize functional structures with different kinetic patterns. PCA and ICA assume sources are statistically uncorrelated or independent and don't perform well when correlated sources are present. In this paper, we deduce the relationship between the measured imaging data and the kinetic patterns and present a temporal unmixing approach, which is based on nonnegative blind source separation (BSS) method with a convex analysis framework to separate the measured data. The presented method requires no assumption on source independence or zero correlations. Several numerical simulations and phantom experiments are conducted to investigate the performance of the proposed temporal unmixing method. The results indicate that it is feasible to unmix the measured data before the tomographic reconstruction and the BSS based method provides better unmixing quality compared with PCA and ICA.
Related Links	http://dx.doi.org/10.1155/2015/713424
Starting Page	713424
File Format	PDF
ISSN	1748670X
e-ISSN	17486718
Journal	Computational and Mathematical Methods in Medicine
Volume Number	2015
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2015-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Modelling and Simulation Immunology and Microbiology(all) Applied Mathematics Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Applied Mathematics Modeling and Simulation Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Libarray of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Temporal Unmixing of Dynamic Fluorescent Images by Blind Source Separation Method with a Convex Framework

Temporal Unmixing of Dynamic Fluorescent Images by Blind Source Separation Method with a Convex Framework (2015)

Temporal Unmixing of Dynamic Fluorescent Images by Blind Source Separation Method with a Convex Framework.

Probabilistic Source Separation for Robust Fetal Electrocardiography

An Image Registration Method for Colposcopic Images

A Novel Blind Separation Method in Magnetic Resonance Images

Optimal Control of HIV Dynamic Using Embedding Method

Fast and Automatic Ultrasound Simulation from CT Images

Source Space Analysis of Event-Related Dynamic Reorganization of Brain Networks

Temporal Unmixing of Dynamic Fluorescent Images by Blind Source Separation Method with a Convex Framework

Similar Documents

Temporal Unmixing of Dynamic Fluorescent Images by Blind Source Separation Method with a Convex Framework

Temporal Unmixing of Dynamic Fluorescent Images by Blind Source Separation Method with a Convex Framework (2015)

Temporal Unmixing of Dynamic Fluorescent Images by Blind Source Separation Method with a Convex Framework.

Probabilistic Source Separation for Robust Fetal Electrocardiography

An Image Registration Method for Colposcopic Images

A Novel Blind Separation Method in Magnetic Resonance Images

Optimal Control of HIV Dynamic Using Embedding Method

Fast and Automatic Ultrasound Simulation from CT Images

Source Space Analysis of Event-Related Dynamic Reorganization of Brain Networks

Temporal Unmixing of Dynamic Fluorescent Images by Blind Source Separation Method with a Convex Framework