NDLI: Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells

Content Provider	PubMed Central
Author	Ropero, Ana B. Paloma, Alonso-magdalena Soriano, Sergi Pablo, Juan-picó Roepke, Troy A. Kelly, Martin J. Nadal, Ángel
Editor	Manuel, Tena-sempere
Copyright Year	2012
Abstract	The non-steroidal compound STX modulates the hypothalamic control of core body temperature and energy homeostasis. The aim of this work was to study the potential effects of STX on pancreatic β-cell function. 1–10 nM STX produced an increase in glucose-induced insulin secretion in isolated islets from male mice, whereas it had no effect in islets from female mice. This insulinotropic effect of STX was abolished by the anti-estrogen ICI 182,780. STX increased intracellular calcium entry in both whole islets and isolated β-cells, and closed the KATP channel, suggesting a direct effect on β-cells. When intraperitoneal glucose tolerance test was performed, a single dose of 100 µg/kg body weight STX improved glucose sensitivity in males, yet it had a slight effect on females. In agreement with the effect on isolated islets, 100 µg/kg dose of STX enhanced the plasma insulin increase in response to a glucose load, while it did not in females. Long-term treatment (100 µg/kg, 6 days) of male mice with STX did not alter body weight, fasting glucose, glucose sensitivity or islet insulin content. Ovariectomized females were insensitive to STX (100 µg/kg), after either an acute administration or a 6-day treatment. This long-term treatment was also ineffective in a mouse model of mild diabetes. Therefore, STX appears to have a gender-specific effect on blood glucose homeostasis, which is only manifested after an acute administration. The insulinotropic effect of STX in pancreatic β-cells is mediated by the closure of the KATP channel and the increase in intracellular calcium concentration. The in vivo improvement in glucose tolerance appears to be mostly due to the enhancement of insulin secretion from β-cells.
Related Links	http://dx.doi.org/10.1371/journal.pone.0034650
Starting Page	34650
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	4
Volume Number	7
Language	English
Publisher	Public Library of Science
Publisher Date	2012-04-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Correction: Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells

Correction: Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells

Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells

Correction: Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells

Correction: Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells.

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Correction: Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells

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