NDLI: Causal Modeling of Gene Regulatory Network

Content Provider	IEEE Xplore Digital Library
Author	Ram, R. Chetty, M. Dix, T.I.
Copyright Year	2006
Description	Author affiliation: Fac. of Inf. Technol., Monash Univ., Churchill, Vic. (Ram, R.; Chetty, M.; Dix, T.I.)
Abstract	The analysis of high-throughput experimental data, such as microarray gene expression data, is currently seen as a promising way of finding regulatory relationships between genes. Network inference algorithms are powerful computational tools for identifying putative causal interactions among variables from observed data. In this paper, we propose a network reconstruction technique to predict not only the structure but also the direction and sign of regulation using a genetic algorithm (GA). The networks consisting of nodes (genes), directed edges (gene-gene interactions) and dynamics of regulation are assigned scores using the presented causal model based on partial correlation. The highest scoring network best fits the expression data. As GAs are stochastic, the algorithm is repeated several times and the final network is reconstructed by combining the most significant connections identified from the high scoring networks. The presented technique is applied to the well known Saccharomyces cerevisiae microarray dataset and the reconstructed network is observed to be consistent with the results found in literature
Starting Page	1
Ending Page	8
File Size	278713
Page Count	8
File Format	PDF
ISBN	1424406234
DOI	10.1109/CIBCB.2006.330982
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-09-28
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Gene expression Biological system modeling Genetic algorithms Biomedical measurements Reverse engineering Bayesian methods Information technology Australia Information analysis Inference algorithms
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Libarray of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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