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Devices, Systems, and Methods for Magnetic Resonance Imaging (mri)-guided Procedures
| Content Provider | The Lens |
|---|---|
| Description | L'invention concerne des dispositifs, des systèmes et des procédés à utiliser dans une intervention guidée par imagerie par résonance magnétique (IRM), dans laquelle de l'énergie focalisée est appliquée à une zone d'intérêt d'un sujet. L'invention concerne également des bains de couplage qui comprennent une solution aqueuse comportant une pluralité de particules paramagnétiques dispersées dans l'eau ; lorsque des images par résonance magnétique sont prises de la zone d'intérêt du sujet pour un guidage par IRM, le bain de couplage étant situé à proximité de la zone d'intérêt, et la composition, la taille moyenne des particules, la forme, la concentration, la présence ou l'absence de la couche de couverture, l'identité de la pluralité de ligands lorsque la couche de couverture est présente, l'épaisseur moyenne de la couche de couverture lorsque cette dernière est présente, ou une association de ces dernières, étant sélectionnées de telle sorte que le bain de couplage réduit ou empêche des artéfacts d'imagerie dans les images par résonance magnétique pour le guidage par IRM. |
| Abstract | Disclosed herein are devices, systems, and methods for use in a magnetic resonance imaging (MRI)-guided procedure in which focused energy is applied to an area of interest of a subject. Disclosed herein are coupling baths comprising an aqueous solution comprising a plurality of paramagnetic particles dispersed in water, wherein, when magnetic resonance images are collected from the area of interest of the subject for MRI guidance: the coupling bath is located proximate to the area of interest, and the composition, the average particle size, the shape, the concentration, the presence or absence of the capping layer, the identity of the plurality of ligands when the capping layer is present, the average thickness of the capping layer when the capping layer is present, or a combination thereof is/are selected such that the coupling bath reduces or prevents imaging artifacts in the magnetic resonance images for the MRI guidance. |
| Related Links | https://www.lens.org/lens/patent/196-654-315-477-083/frontpage |
| Language | English |
| Publisher Date | 2021-03-25 |
| Access Restriction | Open |
| Alternative Title | Dispositifs, Systèmes Et Procédés Destinés À Des Interventions Guidées Par Imagerie Par Résonance Magnétique (irm) |
| Content Type | Text |
| Resource Type | Patent |
| Date Applied | 2020-09-19 |
| Agent | Near, Rachel D. Et Al. |
| Applicant | Univ Virginia Patent Foundation Virginia Tech Intellectual Properties Inc |
| Application No. | 2020051681 |
| Claim | A coupling bath for use in a magnetic resonance imaging (MRI)-guided procedure in which focused energy is applied to an area of interest of a subject, the coupling bath comprising: an aqueous solution comprising a plurality of paramagnetic particles dispersed in water, each of the plurality of paramagnetic particles having a composition, an average particle size, a shape, a concentration, and an optional capping layer, the optional capping layer, when present, comprising a plurality of ligands attached to a surface of the paramagnetic particle and having an average thickness, wherein, when magnetic resonance images are collected from the area of interest of the subject for the MRI guidance: the coupling bath is located proximate to the area of interest, and the composition, the average particle size, the shape, the concentration, the presence or absence of the capping layer, the identity of the plurality of ligands when the capping layer is present, the average thickness of the capping layer when the capping layer is present, or a combination thereof is/are selected such that the coupling bath reduces or prevents imaging artifacts in the magnetic resonance images for the MRI guidance. The coupling bath of claim 1, wherein the plurality of paramagnetic particles are biocompatible. The coupling bath of claim 1 or claim 2, wherein the plurality of paramagnetic particles comprise a metal selected from the group consisting of Fe, Mn, Ni, Gd, and combinations thereof. The coupling bath of any one of claims 1-3, wherein the plurality of paramagnetic particles comprise Fe. The coupling bath of any one of claims 1-4, wherein the plurality of paramagnetic particles comprise an iron oxide. The coupling bath of any one of claims 1-5, wherein the plurality of paramagnetic particles comprise Fe3O4. The coupling bath of any one of claims 1-6, wherein the plurality of paramagnetic particles have an average particle size of 250 nanometers (nm) or less, 100 nm or less, or 50 nm or less. The coupling bath of any one of claims 1-7, wherein the plurality of paramagnetic particles have an average particle size of from 30 nm to 50 nm. The coupling bath of any one of claims 1-8, wherein the plurality of paramagnetic particles are substantially spherical in shape. The coupling bath of any one of claims 1-9, wherein each of the plurality of paramagnetic particles further comprises a capping layer comprising a plurality of ligands, the plurality of ligands being attached to a surface of each of the plurality of paramagnetic particles. The coupling bath of any one of claims 1-10, wherein the plurality of ligands are hydrophilic such that the capping layer is hydrophilic. The coupling bath of any one of claims 1-11, wherein the plurality of ligands comprise poly((meth)acrylic acid). The coupling bath of any one of claims 1-12, wherein the capping layer has an average thickness of from 1 nm to 10 nm. The coupling bath of any one of claims 1-13, wherein the plurality of paramagnetic particles have a concentration of 10 mM or less, 5 mM or less, or 1 mM or less in the coupling bath. The coupling bath of any one of claims 1-14, wherein the coupling bath has an r2 relaxivity of 20 per second per mM or more and/or an R2 relaxation rate of 20 per second or more when subjected to multi-spin-echo measurements on a 1.5T or 3T MRI scanner. The coupling bath of any one of claims 1-15, wherein the coupling bath has a T2 relaxation time of 50 ms or less when subjected to multi-spin-echo measurements on a 1.5T or 3T MRI scanner. The coupling bath of any one of claims 1-16, wherein the coupling bath has a probability of cavitation is 0.5 or less for a peak negative pressure of 30 mega pascals (MPa) or less when subjected to highly focused, shocked, 5 cycle pulses at a pulse rate of 1 Hz. The coupling bath of any one of claims 1-17, wherein the coupling bath has a cavitation duty cycle of 0.5 or less for a peak negative pressure of 30 MPa or less when subjected to continuous wave acoustic soni cations with acoustic powers of from 1 to 1000 W for 10 seconds. The coupling bath of any one of claims 1-18, wherein the coupling bath has an MR signal in a T2 and/or T2*-weighted image that is less than the corresponding MR signal from a corresponding coupling bath in the absence of the plurality of paramagnetic particles by 50% or more, 75% or more, 90% or more, 95% or more, or 99% or more. The coupling bath of any one of claims 1-19, wherein the coupling bath has a peak temperature change that is different than the corresponding peak temperature change for a corresponding coupling bath in the absence of the plurality of paramagnetic particles by 10% or less, 5% or less, or 1 % or less, when insonated for 10 seconds at an acoustic power of from 50 to 1000 W. The coupling bath of any one of claims 1-20, wherein the coupling bath has a peak temperature change that is different than the corresponding peak temperature change for a corresponding coupling bath in the absence of the plurality of paramagnetic particles by 5°C or less, when insonated for 10 seconds at an acoustic power of from 50 to 1000 W. The coupling bath of any one of claims 1-21, wherein the coupling bath has similar mechanical, thermal, acoustic, and/or electromagnetic properties as a corresponding coupling bath in the absence of the plurality of paramagnetic particles. A method for a magnetic resonance imaging (MRI)-guided procedure on a subject wherein focused energy is applied to an area of interest of the subject, the method comprising providing the coupling bath of any one of claims 1-22 proximate the area of interest, such that, when magnetic resonance images are collected from the area of interest of the subject for the MRI guidance, the coupling bath reduces or prevents imaging artifacts in the magnetic resonance images for the MRI guidance. The method of claim 23, wherein the use of the coupling bath of any one of claims 1-22 improves the image-guidance and/or safety of the MRI guided procedure relative to a corresponding coupling bath in the absence of the plurality of paramagnetic particles. The method of claim 23 or claim 24, wherein the method further comprises collecting magnetic resonance images from the area of interest of the subject for the MRI guidance. The method of any one of claims 23-25, wherein the magnetic resonance images for the MRI guidance are collected intraoperatively. The method of any one of claims 23-26, further comprising circulating the coupling bath during the collection of the magnetic resonance images for the MRI guidance. The method of any one of claims 23-27, wherein the MRI-guided procedure comprises MRI-guided microwave ablation, MRI-guided laser interstitial surgery, MRI-guided focused ultrasound (FUS), or a combination thereof. The method of any one of claims 23-28, wherein the focused energy applied to the area of interest in the MRI-guided procedure comprises focused ultrasound (FUS). The method of any one of claims 23-29, wherein the MRI-guided procedure is a transcranial focused ultrasound (T-FUS) procedure. The method of claim 29 or claim 30, wherein the coupling bath is acoustically compatible with clinical transcranial FUS procedures. The method of any one of claims 29-31, wherein the prefocal acoustic field is below the 0.5 cavitation probability threshold of the coupling bath. The method of any one of claims 29-32, wherein the prefocal acoustic field is below the non-trivial cavitation probability threshold of the coupling bath. A system for a magnetic resonance imaging (MRI)-guided procedure on a subject wherein focused energy is applied to an area of interest of the subject, the system comprising the coupling bath of any one of claims 1-22 proximate the area of interest and a magnetic resonance imaging device configured to collect images from the area of interest of the subject for the MRI guidance, wherein when the magnetic resonance images are collected from the area of interest of the subject for MRI guidance, the coupling bath reduces or prevents imaging artifacts in the magnetic resonance images for the MRI guidance. The system of claim 34, further comprising a device configured to apply focused energy to the area of interest in the subject. The system of claim 35, wherein the device configured to apply focused energy to the area of interest in the subject comprises a transcranial focused ultrasound (T-FUS) device. The system of claim 36, wherein the T-FUS device comprises a transducer and the coupling bath is located between the transducer and the area of interest of the subject. The system of any one of claims 34-37, wherein the system further comprises a means for circulating the coupling bath. |
| CPC Classification | Diagnosis; Surgery; Identification Electrotherapy;Magnetotherapy;Radiation Therapy;Ultrasound Therapy Measuring Electric Variables;Measuring Magnetic Variables |
| Extended Family | 046-389-448-564-195 177-155-403-601-237 196-654-315-477-083 022-141-223-372-58X |
| Patent ID | 2021055889 |
| Inventor/Author | Allen Steven P Meyer Craig H Vlaisavljevich Eli Davis Richey M Fergusson Austin D Edsall Connor W |
| IPC | A61N7/00 A61N5/00 |
| Status | Pending |
| Simple Family | 046-389-448-564-195 177-155-403-601-237 196-654-315-477-083 022-141-223-372-58X |
| CPC (with Group) | A61B18/1815 A61B18/20 A61B2090/374 A61N7/02 A61N2007/0095 A61N2007/0082 A61N2007/0073 A61N2007/0078 G01R33/4814 G01R33/56563 G01R33/4804 A61B8/4281 A61B90/37 A61B5/055 |
| Issuing Authority | World Intellectual Property Organization (WIPO) |
| Kind | Patent Application Publication |
