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Lysozyme Transgenic Ungulates
| Content Provider | The Lens |
|---|---|
| Description | L'invention concerne des ongulés transgéniques comprenant un transgène qui code la lysozyme, et des procédés de production desdits animaux. L'invention concerne en outre des procédés de production d'un produit alimentaire, de type lait, ou produit laitier, faisant intervenir un sujet ongulé transgénique, ainsi que des produits alimentaires obtenus à partir d'un sujet ongulé transgénique. |
| Abstract | The present invention provides transgenic ungulates that include a transgene that encodes lysozyme, and methods for producing such animals. The invention further provides methods of producing a food product, such as milk, or a milk product, using a subject transgenic ungulate, as well as food products harvested from a subject transgenic ungulate. |
| Related Links | https://www.lens.org/images/patent/WO/2004063346/A2/WO_2004_063346_A2.pdf |
| Language | English |
| Publisher Date | 2004-07-29 |
| Access Restriction | Open |
| Alternative Title | Ongules Transgeniques A Transgene Codant La Lysozyme |
| Content Type | Text |
| Resource Type | Patent |
| Date Applied | 2004-01-08 |
| Agent | Borden, Paula, A. |
| Applicant | Univ California Murray James D Anderson Gary B Maga Elizabeth A |
| Application No. | 2004000501 |
| Claim | A transgenic ungulate comprising a transgene encoding lysozyme. The transgenic ungulate of claim 1, wherein said ungulate is female, and wherein said lysozyme-encoding transgene is expressed in mammary gland cells of said ungulate, and wherein milk produced by said transgenic ungulate has a level of lysozyme that is at least about 10% higher than the level of lysozyme in milk of a non-transgenic ungulate of the same species. The transgenic ungulate of claim 2, wherein said transgene comprises a coding sequence for lysozyme operably linked to a mammary specific promoter. The transgenic ungulate of claim 1 , wherein said ungulate is male. The transgenic ungulate of claim 1 , wherein said ungulate is a goat. The transgenic ungulate of claim 1, wherein said transgene is chromosomally integrated. The transgenic ungulate of claim 1 , wherein said ungulate is heterozygous for the transgene. The transgenic ungulate of claim 1, wherein said ungulate is homozygous for the transgene. The transgenic ungulate of claim 1, wherein the transgene encodes human lysozyme. An isolated fertilized egg, wherein said egg is isolated from a transgenic ungulate comprising a transgene encoding lysozyme. A composition comprising an isolated fertilized egg according to claim 10; and a cryoprotective agent. A method of producing a food product, said method comprising harvesting a food product from a transgenic ungulate of claim 2. A method of producing a food product, the method comprising processing a food product harvested from a transgenic ungulate of claim 2. A method of producing cheese, the method comprising: a) adding rennet to milk harvested from a transgenic ungulate according to claim 2; b) allowing curd formation to occur; and c) producing cheese from the curds. A milk product produced by a transgenic ungulate of claim 2, wherein said milk product has a level of lysozyme that is at least about 10% higher than the level of lysozyme in milk of a non-transgenic ungulate of the same species. The milk product of claim 15, wherein the milk product has reduced rennet clotting time compared to a milk product of a non-transgenic animal of the same species. A processed milk produced from milk of a transgenic ungulate of claim 2. The processed milk product of claim 17, wherein the processed milk product is cheese. The processed milk product of claim 18, wherein the cheese has increased gel strength compared to cheese made from milk of a non-transgenic ungulate of the same species. |
| CPC Classification | Animal Husbandry; Aviculture; Apiculture; Pisciculture; Fishing; Rearing Or Breeding Animals; Not Otherwise Provided For; New Breeds Of Animals MICROORGANISMS OR ENZYMES;COMPOSITIONS THEREOF;PROPAGATING; PRESERVING; OR MAINTAINING MICROORGANISMS;MUTATION OR GENETIC ENGINEERING;CULTURE MEDIA |
| Extended Family | 092-347-146-602-814 016-343-653-919-555 130-427-235-208-647 |
| Patent ID | 2004063346 |
| Inventor/Author | Murray James D Anderson Gary B Maga Elizabeth A |
| IPC | A01K67/027 A23C19/00 C12N/ C12N5/00 C12N9/36 C12N15/85 C12P21/00 |
| Status | Pending |
| Simple Family | 130-427-235-208-647 016-343-653-919-555 092-347-146-602-814 |
| CPC (with Group) | A01K67/0275 A01K2217/05 A01K2227/102 A01K2267/02 C12N9/2462 C12N15/8509 |
| Issuing Authority | World Intellectual Property Organization (WIPO) |
| Kind | Patent Application Publication (Republication) |
