NDLI: Substituted N-phenyl-2-cyano-3-hydroxy-enamides

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Substituted N-phenyl-2-cyano-3-hydroxy-enamides

Content Provider	The Lens
Abstract	Compounds of formula (I) (I) ¢wherein R1 represents a group of formula , , or (in which R13, R14 and R15, which may be the same or different, each represents a hydrogen atom, a halogen atom or an alkyl group containing 1 to 3 carbon atoms and n represents 1, 2 or 3); R2 represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms; R3, R4, R5, R6 and R7, which may be the same or different, each represents a hydrogen atom, a halogen atom, a group NO2, a cyano group, a linear or branched alkyl group containing 1 to 6 carbon atoms, a linear or branched alkylcarbonyl group containing 2 to 6 carbon atoms, a cycloalkyl group containing 3 to 6 carbon atoms, a linear or branched alkoxy group containing 1 to 6 carbon atoms, a linear or branched alkylthio group containing 1 to 6 carbon atoms, a group selected from -(CH2)m-CF3, -O-(CH2)m-CF3, -S-(CH2)m-CF3, -CF2-Hal, -O-CF2-Hal, , , , and (wherein m represents 0, 1, 2 or 3; n represents 1, Z or 3; Hal, Hall, Hal2 and Hal3, which may be the same or different, each represents a halogen atom) or a group of formula (wherein R8, R9, R10, R11 and R12, which may be the same or different, each represents any of those groups defined above for R3, R4, R5, R6 and R7); or R4 and R5 together represent a group -O-CH2-O-,whilst R3, R6 and R7 are as defined above!; and base addition salts thereof, possess anti-inflammatory and immunomodulatory activity. Processes for preparing them, intermediate compounds used in their preparation and compositions containing them are also described.
Related Links	https://www.lens.org/images/patent/EP/0551230/B1/EP_0551230_B1.pdf
Language	English
Publisher Date	1993-07-09
Access Restriction	Open
Alternative Title	N-phenyl-2-cyano-3-hydroxy-enamides Substitues
Content Type	Text
Resource Type	Patent
Jurisdiction	Canada
Date Applied	1993-01-07
Applicant	Roussel Uclaf
Application No.	2086908
CPC Classification	ACYCLIC OR CARBOCYCLIC COMPOUNDS Specific Therapeutic Activity Of Chemical Compounds Or Medicinal Preparations Preparations For Medical; Dental Or Toiletry Purposes
Extended Family	064-486-292-320-537 045-321-122-817-992 021-023-697-361-248 004-609-706-247-992 146-690-946-679-495 120-272-252-462-78X 077-758-655-333-678 020-255-134-924-162 055-221-635-932-405 069-123-489-395-849 094-688-902-565-851 058-033-589-251-545 074-848-922-101-311 114-660-368-328-379 024-893-076-924-384 198-634-410-220-539 031-588-405-953-964 141-704-709-164-79X 021-364-436-475-269 012-604-429-790-192 140-979-507-063-778 167-997-076-048-013 139-435-559-007-152 165-376-672-845-831 021-600-518-980-893 029-303-034-685-388 120-681-869-257-791 147-726-097-582-442 003-899-325-125-299 163-462-271-391-101 026-355-251-340-891 062-059-386-251-019 177-771-656-503-028 104-432-333-351-213 172-918-319-004-246 110-630-516-748-736 154-289-029-941-192 130-231-365-165-759
Inventor/Author	Bartlett Robert R Kay David P Kuo Elizabeth A Schleyerbach Rudolf Schwab Wilfried
IPC	A61K31/165 A61K31/275 A61K31/277 A61P29/00 C07C255/19 C07C255/23 C07C255/26 C07C255/60 C07C255/61 C07C323/41
Status	Expired
Simple Family	064-486-292-320-537 045-321-122-817-992 021-023-697-361-248 004-609-706-247-992 146-690-946-679-495 120-272-252-462-78X 077-758-655-333-678 020-255-134-924-162 055-221-635-932-405 069-123-489-395-849 094-688-902-565-851 058-033-589-251-545 074-848-922-101-311 114-660-368-328-379 024-893-076-924-384 198-634-410-220-539 031-588-405-953-964 141-704-709-164-79X 021-364-436-475-269 012-604-429-790-192 140-979-507-063-778 167-997-076-048-013 139-435-559-007-152 165-376-672-845-831 021-600-518-980-893 029-303-034-685-388 120-681-869-257-791 147-726-097-582-442 003-899-325-125-299 163-462-271-391-101 026-355-251-340-891 062-059-386-251-019 177-771-656-503-028 104-432-333-351-213 172-918-319-004-246 110-630-516-748-736 154-289-029-941-192 130-231-365-165-759
CPC (with Group)	C07C255/19 A61P29/00 C07C255/23 A61K31/275
Issuing Authority	European Patent Office (EPO)
Kind	Patent Application Publication

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