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Author Sinha, P. K. ♦ Neema, P. K. ♦ Rathod, Ramesh Chandra
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Anaesthesia and Intensive Care
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Diseases
Subject Domain (in MeSH) Therapeutics ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment
Subject Keyword Critical Care
Abstract In a randomized, double-blind, prospective trial we compared the efficacy of pre-treatment with nitrous oxide (with or without premixed lignocaine in propofol) for the prevention of propofol-induced pain. Ninety consecutive patients were recruited in the study and divided into three groups of 30 each, who received either 50% nitrous oxide in oxygen along with lignocaine 40 mg mixed in 1% propofol 20 ml (Group NL), 50% nitrous oxide in oxygen without lignocaine in propofol (Group N), and 50% oxygen in air with lignocaine mixed in propofol 40 mg (Group L). Pain scores were graded on a four point verbal rating scale (0-3). Eighty-nine patients completed the study while one patient developed excitement, agitation and tremor during nitrous oxide in oxygen inhalation. Eleven patients (36.7%) complained of pain in the group L compared to 7 (23.3%), and 1 (3.3%), in groups N and NL respectively [group NL vs group L (P< 0.001) and group NL vs N (P< 0.001)]. There was no statistical difference observed between group N and group L. Inhalation of 50% nitrous oxide reduces pain on propofol injection. The combination of 50% nitrous oxide and lignocaine mixed with propofol was the most effective treatment.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Volume Number 33
Issue Number 2
Page Count 4
Starting Page 235
Ending Page 238