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Author Mohanan, P. V. ♦ Devi, K. S.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Journal of Experimental & Clinical Cancer Research
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Pharmacology and therapeutics
Subject Domain (in MeSH) Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment
Subject Keyword Toxicology
Abstract The partially purified component of Solanum trilobatum named as Sobatum was found to be cytotoxic in Dalton's lymphoma ascites (DLA), Ehrlich ascites (EA) and tissue cultured cells. It significantly inhibited the peritoneal and solid tumours induced by DLA and EA tomour cells along with the chemically induced skin carcinogenesis. Sobatum did not produce any chromosomal anomalies in the bone marrow cells of Swiss mice. In the present study, we have evaluated the chemoprotective effect of Sobatum on cyclophosphamide induced toxicity in mice. The results showed that the co-administration of Sobatum increase the total leucocyte count, haemoglobin level, average life span of animals; we, concluded that Sobatum has chemoprotective action on cyclophosphamide induced toxicity.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Volume Number 17
Issue Number 2
Page Count 6
Starting Page 159
Ending Page 164