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Author Radhakrishnan, V. V.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Cardiovascular Research
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Pharmacology and therapeutics
Subject Domain (in MeSH) Cardiovascular Diseases ♦ Diseases ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment
Subject Keyword Experimental Medicine
Abstract In guinea-pigs, myocarditis was induced under experimental conditions by immunizing the animals with rabbit skeletal muscle myosin-beta. The salient histopathological features were foci of perivascular lymphonononuclear aggregates, necrosis, and degeneration of myocardial cells. Antimyosin-beta antibodies in the immune complexes were demonstrated in the sera of the guinea-pigs. An immune-complex-mediated tissue-injury is proposed in the pathogenesis of myocarditis.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Volume Number 31
Issue Number 4
Page Count 4
Starting Page 651
Ending Page 654