|Author||Victor, S. P. ♦ Sharma, C. P.|
|Source||Sree Chitra Tirunal Institute for Medical Sciences & Technology|
|Publisher||Journal of Biomaterials Applications|
|Subject Domain (in DDC)||Technology ♦ Medicine & health ♦ Pharmacology and therapeutics|
|Subject Domain (in MeSH)||Therapeutics ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment|
|Subject Keyword||Drug Delivery|
|Abstract||This study investigated polymethacrylic acid (PMAA) microparticles for controlled release of Insulin in oral administration. The microparticles were characterised by scanning electron microscopy (SEM) for morphological studies. The swelling behaviour and drug release profile in various pH media were studied. The % swelling of gels was found to be inversely related to the amount of crosslinker added. Inclusion complex of betaCD and Insulin was studied using polyacrylamide gel electrophoresis (PAGE). Optimum complexation was obtained in the ratio 100 mg betaCD: 200IU Insulin. The release pattern of Insulin from Insulin-betaCD complex encapsulated PMAA microparticles showed release of Insulin for more than seven hours.|
|Education Level||UG and PG|
|Learning Resource Type||Article|
|Educational Framework||Medical Council of India (MCI)|
|Journal||JOURNAL OF BIOMATERIALS APPLICATIONS|
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