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Author Mohanan, P. V. ♦ Rathinam, K.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Veterinary and Human Toxicology
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Pharmacology and therapeutics
Subject Domain (in MeSH) Pathological Conditions, Signs and Symptoms ♦ Diseases ♦ Lipids ♦ Chemicals and Drugs ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment
Subject Keyword Toxicology
Abstract This study evaluated the teratogenic defects of rat brain, eye, heart, urogenital and skeletal systems after po administration of bone wax saline extract on days 9-13 of gestation. The experiment involved 5 groups of 6 pregnant wistar rats each. The vehicle control group received only 50.0 ml distilled water/kg; 3 test groups received 12.5, 25.0 or 50.0 ml of bone wax saline extract/kg; and the last group received 100 mg caffeine/kg as positive control. On the 21st day of gestation all the animals were sacrificed under ether anesthesia and fetuses were collected for routine teratological evaluations. There was no significant change in maternal body weight or food consumption and no external, visceral, skeletal and histological abnormalities in the vehicle control and bone wax dosed groups. Abnormalities were observed in the positive control group.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Volume Number 36
Issue Number 2
Page Count 3
Starting Page 125
Ending Page 127