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Author Hari, P. R. ♦ Naseerali, C. P. ♦ Sreenivasan, K.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Journal of Chromatography B-analytical Technologies In The Biomedical and Life Sciences
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Incidence & prevention of disease
Subject Domain (in MeSH) Organic Chemicals ♦ Chemicals and Drugs ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Environment and Public Health ♦ Health Care
Subject Keyword Sterilization
Abstract A novel analytical methodology for the estimation of residual ethylene glycol (EG) in ethylene oxide sterilized polymer is reported. The method involves the monitoring of ammonium adduct of EG ions in the presence of 10 mM ammonium acetate buffer and methanol using electrospray ionization liquid chromatography and mass spectrometry (LC-ESI-MS). The method enables the detection and quantification of EG without prior derivatization up to a level of 0.06 mu g/ml. The potentiality of the method is demonstrated by estimating EG in ethylene oxide (EtO) sterilized polyethylene terephthalate fabric used in heart valve sewing ring. The method is simple, rapid and can routinely be used for the quantification of residual EG in EtO sterilized medical devices. (c) 2008 Elsevier B.V. All rights reserved.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Journal JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume Number 877
Issue Number 3
Page Count 5
Starting Page 328
Ending Page 332