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Author Katti, M. K.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Archives of Medical Research
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Diseases
Subject Domain (in MeSH) Hemic and Immune Systems ♦ Anatomy ♦ Bacterial Infections and Mycoses ♦ Diseases ♦ Diagnosis ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment
Subject Keyword Immunology
Abstract Background and Aims. Tuberculosis (Tb) infection is controlled by cell-mediated immunity through mediation of IL-1, IL-2 and IFN-gamma. In this study IL-1, IL-2 and IFN-gamma were determined in serum samples of untreated pulmonary Tb and control group including apparently healthy individuals or contacts and normal healthy blood donors with an objective of understanding defect(s), if any, in synthesis of any of these cytokines that may lead to a diseased state of Tb.Methods. IL-1, IL-2 and IFN-gamma were measured in serum samples of untreated Tb patients (n = 33), contacts (n = 19) and healthy individuals (n = 20) by commercially available monoclonal antibody-based ELISA.Results. Statistically significant differences in IL-1 and IFN-gamma concentrations between groups of pulmonary Tb and controls were observed, whereas no significant difference in IL-2 was seen.Conclusions. In the present study, increased levels of cytokines in patients with pulmonary Tb are indicative of Th1 response. An increased level of cytokine (IFN-gamma) in patients with untreated pulmonary Tb appears to be functionally defective. (C) 2011 IMSS. Published by Elsevier Inc.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Journal ARCHIVES OF MEDICAL RESEARCH
Volume Number 42
Issue Number 3
Page Count 3
Starting Page 199
Ending Page 201