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Author Jayabalan, M. ♦ Shalumon, K. T. ♦ Mitha, M. K. ♦ Ganesan, K. ♦ Epple, M.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Acta Biomaterialia
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Domain (in MeSH) Immune System Phenomena ♦ Biological Sciences
Subject Keyword Biocompatibility
Abstract The effect of hydroxyapatite (HAP) on the performance of nanocomposites of an unsaturated polyester, i.e. hydroxy-terminated high molecular weight poly(proplyene fumarate) (HT-PPFhm), was investigated A thermoset nanocomposite was prepared with nanoparticles of calcined HAP (<100 nm, rod-like shape, filler content 30 wt %), HT-PPFhm and N-vinyl pyrrolidone, dibenzoyl peroxide and N,N-dimethyl aniline. Two more nanocomposites were prepared with precipitated HAP nanoparticles (<100 nm rod-like shape) and commercially available HAP nanoparticles (<200 nm spherical shape), respectively Calcined HAP nanoparticles resulted in very good crosslinking in the resin matrix with high crosslinking density and Interfacial bonding with the polymer. owing to the rod-like shape of the nanoparticles, this gave improved biomechanical strength and modulus and also controlled degradation of the nanocomposite for scaffold formation The tissue compatibility and osteocompatibility of the nanocomposite containing calcined HAP nanoparticles was evaluated The tissue compatibility was Studied by Intramuscular implantation in a rabbit animal model for 3 months as per ISO standard 10993/6 The in vivo femoral bone repair was also carried out in the rabbit animal model as per ISO standard 10993/6 The nanocomposite containing calcined HAP nanoparticles is both biocompatible and osteocompatible (C) 2009 Acta Materialia Inc Published by Elsevier Ltd All rights reserved.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Journal ACTA BIOMATERIALIA
Volume Number 6
Issue Number 3
Page Count 13
Starting Page 763
Ending Page 775