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Author Thanoo, B. C. ♦ Sunny, M. C. ♦ Jayakrishnan, A.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Biomaterials
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Domain (in MeSH) Biomedical and Dental Materials ♦ Chemicals and Drugs
Subject Keyword Biomaterials
Abstract Polyurethane microspheres having diameters in the range 150-1500-mu-m were prepared by condensation polymerization of toluene diisocyanate (TDI) with poly(tetramethylene glycol) (PTMG) of average mol wt 990 in an aqueous dispersion medium containing dioctyl sulphosuccinate (DOS) as the suspension stabilizer and 1,4-diazabicyclo[2.2.2]octane (DABCO) as the catalyst for polymerization. Incorporation of tantalum powder in the polymerizing phase led to the formation of Ta-loaded microspheres with good radiopacity. Microspheres were surface-modified by grafting methacrylic acid (MA) on to them using gamma-radiation from a Co60 source. Conversion of the grafted MA into its sodium salt imparted hydrophilicity and slipperiness to the microspheres enabling them to pass through Teflon(R) cathers without obstructing the catheter lumen. These microspheres may find application as radiopaque embolization agents.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Journal BIOMATERIALS
Volume Number 12
Issue Number 5
Page Count 4
Starting Page 525
Ending Page 528