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Author Kannoth, S. ♦ Iyer, Rajesh ♦ Thomas, S. V. ♦ Furtado, Sunil V. ♦ Rajesh, B. J. ♦ Kesavadas, C. ♦ Radhakrishnan, V. V. ♦ Sarma, P. S.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Journal of The Neurological Sciences
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Surgery & related medical specialties
Subject Domain (in MeSH) Nervous System Diseases ♦ Diseases ♦ Surgical Procedures, Operative ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment
Subject Keyword Neurosurgery
Abstract Background: Intracranial infectious aneurysms (IA) are infrequent, but can be fatal.Objectives: To compare the clinical profile of IAs associated with intravascular/systemic infection like infective endocarditis with that associated with local infections like meningitis, orbital cellulitis and cavernous sinus thrombosis.Methods: We analysed all cases of IA, treated in this Institute from 1976 to 2003, in order to identify prognostic factors.Results: There were 25 persons (mean age 24.8 +/- 17.3 years, males 17) with 29 IA (carotid circulation 19, vertebrobasilar circulation 10). Headache (83%) and fever (67%) were the most common presenting symptoms. In contrast to noninfectious aneurysms, intracerebral haemorrhage (60%) and focal signs were more common than subarachnoid haemorrhage (7%) with [A. Sources of infection were cardiac (10), meningitis (12), orbital cellulitis (2) or uncertain (I). Infective agents included bacteria (18), fungi (4), and tubercle bacilli (3). Fifteen]A were distal and 14 were proximal. IAs associated with meningitis were proximal (75%) while those associated with cardiac diseases preferentially involved carotid territory and were distal (p=0.013). The overall mortality was 32%. Survivors were younger than those who expired (p=0.015). Of the sixteen patients treated medically, seven recovered (44%), others (56%)) had treatment failure (three died and six required surgery later). Another five patients underwent early Surgery (one died). Mortality of IA was significantly higher with meningitis, fungal aetiology and vertebrobasilar location.Conclusions: IAs associated with local infections like meningitis had different clinical profile as compared to IAs associated with intravascular/systemic infections like infective endocarditis. (C) 2007 Elsevier B.V. All rights reserved.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Volume Number 256
Issue Number 40910
Page Count 7
Starting Page 3
Ending Page 9