|Author||Krishnamoorthy, K. M. ♦ Dash, P. K.|
|Source||Sree Chitra Tirunal Institute for Medical Sciences & Technology|
|Publisher||Scandinavian Cardiovascular Journal|
|Subject Domain (in DDC)||Technology ♦ Medicine & health ♦ Diseases|
|Subject Domain (in MeSH)||Cardiovascular Diseases ♦ Diseases|
|Abstract||Objective - Atrial contribution to ventricular filling was studied to assess its role in predicting the future development of atrial fibrillation ( AF) in patients with severe mitral stenosis ( MS) and sinus rhythm.Design - Two hundred and eight patients with severe MS and sinus rhythm were followed up for 1 year. Baseline data were compared between group I ( who developed AF at follow- up) and group II ( who maintained sinus rhythm). Left atrial size, severity of MS, velocity time integral ( VTI) of mitral valve flow and VTI due to atrial systole ( A- VTI) were noted. Percentage contribution of A- VTI to the total VTI ( A-%) was calculated. Sensitivity and specificity of A-% to predict the onset of AF was obtained.Results - Left atrial size, severity of MS and total VTI were similar in the two groups. Group I patients were older ( 31.1 +/- 9.1 and 18.4 +/- 6.5 years, respectively, p < 0.03) with smaller A- VTI ( 5.3 +/- 2.2 and 6.7 +/- 3.4 cm, respectively, p < 0.01) and A-% ( 8.9 +/- 1.8 and 11.2 +/- 2.7, respectively, p < 0.003). A-% of < 9% ( mean value of A- VTI in group I) had high sensitivity ( 84%, positive predictive value 76%) and specificity ( 80%, negative predictive value 87%) to predict the development of AF.Conclusion - Atrial contribution to ventricular filling is reduced in patients prone to develop AF ( due to inefficient left atrial contraction, much before its dilatation). It can be used for early identification of patients likely to develop AF with high sensitivity and specificity. It is simple, easily available, cost- effective and will guide earlier intervention and more frequent follow- up. There is a preclinical loss in atrial pump function much before the eventual onset of AF.|
|Education Level||UG and PG|
|Learning Resource Type||Article|
|Educational Framework||Medical Council of India (MCI)|
|Journal||SCANDINAVIAN CARDIOVASCULAR JOURNAL|
Ministry of Human Resource Development (MHRD) under its National Mission on Education through Information and Communication Technology (NMEICT) has initiated the National Digital Library of India (NDLI) project to develop a framework of virtual repository of learning resources with a single-window search facility. Filtered and federated searching is employed to facilitate focused searching so that learners can find out the right resource with least effort and in minimum time. NDLI is designed to hold content of any language and provides interface support for leading vernacular languages, (currently Hindi, Bengali and several other languages are available). It is designed to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is being developed to help students to prepare for entrance and competitive examinations, to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is being developed at Indian Institute of Technology Kharagpur.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Human Resource Development (MHRD), through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
For any issue or feedback, please write to firstname.lastname@example.org