Thumbnail
Access Restriction
Authorized

Author Mohanan, P. V. ♦ Jayasree, R. S. ♦ Gupta, A. K.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Journal of Biomaterials Applications
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Pharmacology and therapeutics
Subject Domain (in MeSH) Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment
Subject Keyword Experimental Medicine
Abstract Solid tumour reducing effect in Swiss albino mice induced with Dalton's Lymphoma Ascites tumour cells (DLA) and Ehrlich Ascites tumour cells (EA) was determined with the application of He-Ne and Nd:YAG lasers along with the photosensitising agent 5-Aminolevulinic acid (ALA). The experiment was designed with six groups and each group consisted of six animals. Animals in Groups I-III were injected with DLA cell lines and Groups IV-VI were injected with EA cell lines (1 x 10(6) in 0.1 ml saline) subcutaneously in the right hind limb of mice to induce solid tumours. The tumour was further treated with photosensitiser induced laser therapy. The hyperthermic effect of Nd:YAG laser on tumour reduction was also evaluated. The results of the study suggest that the combination of He-Ne laser and 1 W Nd:YAG laser along with the photosensitiser 5-Aminolevulinic acid is a very effective therapeutic method for the treatment of tumour of DLA and EA cell lines. It is clear from the results that this mode of therapy very well depends on the type of tumour that has to be treated.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Journal JOURNAL OF BIOMATERIALS APPLICATIONS
Volume Number 16
Issue Number 4
Page Count 8
Starting Page 267
Ending Page 274