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Author Mohan, Neethu ♦ Nair, Prabha D.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Journal of Biomedical Materials Research Part B-applied Biomaterials
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Human physiology
Subject Domain (in MeSH) Musculoskeletal System ♦ Tissues ♦ Cells ♦ Anatomy ♦ Organic Chemicals ♦ Macromolecular Substances ♦ Biomedical and Dental Materials ♦ Chemicals and Drugs ♦ Investigative Techniques ♦ Equipment and Supplies ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment
Subject Keyword Tissue Engineering
Abstract Polycaprolactone is an FDA approved aliphatic polyester that is widely used as a scaffold for tissue engineering. It is hydrophobic and doesn't have any reactive functional groups on the polymer for further modification. Blending with other hydrophilic polymers like polyvinyl alcohol helps to generate a hybrid polymer with better properties. In this study we have been able to fabricate a novel porous 3D scaffold of Semi-IPN Poly (caprolactone)-Poly (vinyl alcohol). The Semi IPN is phase mixed and has synergistic properties of its constituent polymers. The hybrid scaffold is nontoxic and highly hydrophilic with greater percentage of swelling and is also amenable for further modification with bioactive peptides. Although porous with an open interconnected porous structure, the scaffold has adequate mechanical strength to withstand the load imparted by the cells during in vitro culture. Porcine chondrocytes seeded within the unmodified scaffolds secrete extra cellular matrix components revealing that the hybrid scaffold has immense potential for tissue engineering applications. (C) 2007 Wiley Periodicals, Inc.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Issue Number 2
Page Count 11
Starting Page 584
Ending Page 594