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Author Radhakrishnan, V. V. ♦ Nair, M. D. ♦ Kuruvilla, A. ♦ Radhakrishnan, K. ♦ Anandam, R.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Indian Journal of Pediatrics
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Diseases
Subject Domain (in MeSH) Nervous System Diseases ♦ Pathological Conditions, Signs and Symptoms ♦ Diseases
Subject Keyword Pathology
Abstract In this retrospective study the clinical features in 16 children with spinal muscular atrophy (SMA) were reviewed and classified into three stages. The muscle biopsy specimen were routinely processed with liquid-nitrogen-isopentane and 8 micron thick frozen-sections were studied for histochemical changes. The clinical features in Type III SMA resembled with limb-girdle muscular dystrophy and the muscle biopsy was useful in distinguishing these two entities. It is being evaluated that prenatal diagnosis of SMA is possible with DNA technology developed recently in our country.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Journal Indian journal of pediatrics
Volume Number 64
Issue Number 5
Page Count 597
Starting Page 91
Ending Page 687