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Author Balakrishnan, B. ♦ Lesieur, S. ♦ Labarre, D. ♦ Jayakrishnan, A.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Carbohydrate Research
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Domain (in MeSH) Biomedical and Dental Materials ♦ Chemicals and Drugs
Subject Keyword Biomaterials
Abstract Periodate oxidation of sodium alginate in aqueous solution as well as a dispersion in 1: 1 ethanol-water was examined. The oxidation proceeded smoothly in both media, and the kinetics of oxidation was Surprisingly similar. Polymer cleavage was observed in both media. but it was extensive in ethanol-water. The weight-average molar mass (M-w) of the oxidized product obtained from aqueous solution showed a gradual decrease with increase in the periodate concentration, whereas, except for very high periodate equivalent, the change in M-w was not reflected with increase in concentration of periodate in ethanol-water. The oxidized alginate obtained from the ethanol-water mixture was found to be more efficient in crosslinking proteins such as gelatin, leading to hydrogels. Oxidation of a dispersion has the advantage of generating large quantities of the oxidized alginate in higher yield with one reaction using less solvent. (c) 2005 Elsevier Ltd. All rights reserved.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Journal CARBOHYDRATE RESEARCH
Volume Number 340
Issue Number 7
Page Count 5
Starting Page 1425
Ending Page 1429