|Author||Beghi, E. ♦ Annegers, J. F.|
|Source||Sree Chitra Tirunal Institute for Medical Sciences & Technology|
|Subject Domain (in DDC)||Technology ♦ Medicine & health ♦ Diseases|
|Subject Domain (in MeSH)||Nervous System Diseases ♦ Diseases|
|Abstract||The risk of major malformations in the offspring of mothers with epilepsy receiving antiepileptic drugs is 4-8% compared to 2-4% in the general population. Risk factors include daily dose and polytherapy. Selected drugs have been found to be associated NNith a higher risk, of'specific mulfortnations (congenital heart defects and cleft palate with phenytoin and barbiturates: neural tube defects with valproate and carbamazepine). Although some of these findings are unquestionable. several questions are still unsolved depending on the characteristic,, of the target populations. the small samples of patients, and the design and limiting factors of the published reports. In the last decade, pregnancy registries have been activated by collaborative groups of physicians in Europe (EURAP). North America (NAREP). Australia and India (the latter two recently merged into EURAP), to enroll a large number of exposed women to be monitored prospectively with standardized methods and by three pharmaceutical companies marketing lamotrigine, gabapentin and vigabatrin, as part of their post-marketing surveillance. Eden though the structure of these registries and the target Populations should theoretically result in the identification of a sufficient number of women exposed to different drugs and examined for the occurrence of malformations of any type and severity, the implementation of a common database vith information from the existing registries may provide valuable information in a shorter time period, Although differences between some of the registries limit the possibility to pool data a gradual developement of a collaboration is highly desirable to discuss a list of design issues and assess to what extent and how data could be C compared and organized.|
|Education Level||UG and PG|
|Learning Resource Type||Article|
|Educational Framework||Medical Council of India (MCI)|
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