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Author Arjun, G. N. ♦ Ramesh, P.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Journal of Biomedical Materials Research. Part A
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Domain (in MeSH) Organic Chemicals ♦ Biomedical and Dental Materials ♦ Chemicals and Drugs ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment
Subject Keyword Biological Evaluation
Abstract This paper reports the electrospinning of a series of oxidatively stable polycarbonate urethanes (PCU) [carbothane (ECT), bionate (EBN), and chronoflex (ECF)] using N,N-dimethyl formamide and tetrahydrofuran as the mixed solvent. The nonwoven membranes were characterized for their structure, performance, and compatibility with cells. Scanning electron microscope was utilized to study the structural morphology and fiber diameter. Microcomputed tomography (micro-CT) was used to characterize the 3D architecture, pore size distribution, and percentage porosity. All the membranes displayed a porous architecture with average fiber diameter in the range of 1.5-2 mum. Static mechanical tests on the membranes revealed that the tensile strength was greater than 7 MPa and the dynamic mechanical tests showed that the average storage modulus (E(i) ) is 2 MPa at 37�C. PCU membranes were subjected to accelerated in vitro degradation for 90 days in 20% hydrogen peroxide/0.1M cobalt chloride solution. Mechanical characterization of the membranes postdegradation confirmed a 64% reduction in tensile strength for EBN at the end of 90 days where as ECF and ECT did not show any significant mechanical property deterioration in the oxidative medium. Cytotoxicity of the membranes was evaluated using L929 fibroblast cells and the results indicated that all the PCU membranes were cytocompatible and showed good adherence to L929 cells. Accordingly, these results highlight the potential of these fibrous PCU membranes for biomedical applications but further in vivo correlation studies are required for better understanding of the biodegradation and biological efficacy. 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:3042-3050, 2012.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Journal Journal of biomedical materials research
Volume Number 100
Issue Number 11
Page Count 2,993
Starting Page 50
Ending Page 3042