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Author Chanda, J.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Biomaterials
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Diseases
Subject Domain (in MeSH) Cardiovascular Diseases ♦ Diseases ♦ Therapeutics ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment
Subject Keyword Cardiology
Abstract The aim of the present study was to:develop a chemical treatment to eliminate highly antigenic substances, to standardize the glutaraldehyde fixation procedure, to determine the dominant factors contributing to the calcification process and to understand the role of macromolecules like chitosan in the prevention of calcification of bioprosthetic heart valves. Bovine pericardium treated with 5% sodium chloride-trypsin-glutaraldehyde (GA)-chitosan did not calcify at 12 wk in the rat (calcium, 1.1 +/- 0.27 mg/g; von Kossa, O), Slow release of residual GA from the bioprosthesis and free aldehyde groups on that are still considered the dominant factors for enhancing calcification of GA-treated bioprostheses.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Journal BIOMATERIALS
Volume Number 15
Issue Number 6
Page Count 5
Starting Page 465
Ending Page 469