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Author Radhakrishnan, V. V. ♦ Radhakrishnan, N. S. ♦ Rout, D. ♦ Misra, B. K.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher British Journal of Neurosurgery
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health ♦ Diseases
Subject Domain (in MeSH) Neoplasms ♦ Nervous System Diseases ♦ Pathological Conditions, Signs and Symptoms ♦ Diseases
Subject Keyword Pathology
Abstract Paraffin sections of 305 meningeal tumours were analysed for the presence of nucleolar organizer region (Ag-NOR) in the neoplastic cells, using a one step silver-colloidal staining method. The mean (+/- SEM) Ag-NOR counts were 2.73 +/- 0.21 for atypical and 2.91 +/- 0.18 for papillary variants of meningioma. In meningotheliomatous and transitional variants of meningioma, the mean Ag-NOR counts were 1.41 +/- 0.34 and 1.38 +/- 0.31, respectively. The recurrence rates were significantly higher in atypical meningiomas than in other histopathological variants (p < 0.05). Differences in the mean Ag-NOR numbers between meningothelial and transitional variants in their primary and recurrent tumours were not significantly different (p > 0.05). The results of this study indicates that estimation of Ag-NOPs can be applied in predicting the aggressive clinical behaviour of primary meningeal tumours.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Volume Number 7
Issue Number 4
Page Count 5
Starting Page 377
Ending Page 381