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Author Hari, P. R. ♦ Sharma, C. P.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Journal of Biomaterials Applications
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Domain (in MeSH) Immune System Phenomena ♦ Biological Sciences
Subject Keyword Biocompatibility
Abstract Upon exposure to blood, rapid adsorption of proteins is the initial event at the contacting surface, followed by the adhesion of platelets and other blood components. Surfaces absorbing albumin appear to possess antithrombotic character in discouraging adhesion of platelets. Therefore, for the development of a blood contacting device, the interfacial events are extremely important and need serious investigation. We have attempted to observe the variations in competitive adsorption of fibrinogen and albumin onto the polyetherurethane urea (PEUU) surface in the presence of external lubricant, such as calcium stearate and silicone fluid coating. It seems, in the presence of such mediators, that fibrinogen adsorption is increased relatively with reduction in albumin at the surface.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Journal Journal of biomaterials applications
Volume Number 7
Issue Number 4
Page Count 295
Starting Page 81
Ending Page 375