|Author||Paul, W. ♦ Sharma, C. P.|
|Source||Sree Chitra Tirunal Institute for Medical Sciences & Technology|
|Publisher||Journal of Biomaterials Science-polymer Edition|
|Subject Domain (in DDC)||Technology ♦ Medicine & health ♦ Pharmacology and therapeutics|
|Subject Domain (in MeSH)||Therapeutics ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment|
|Subject Keyword||Drug Delivery|
|Abstract||Membranes developed from poly(vinyl alcohol) (PVA) have superior permeability because of the highly hydrophilic character of PVA. However, its blood compatibility needs to be further improved. For this we have developed acetylsalicylic acid (ASA, aspirin) loaded PVA membranes. It seems that the slow release of aspirin from the membrane provides a surface concentration of aspirin sufficient for partially inhibiting platelet adhesion. PVA membrane with 531 mu g cm(-2) of ASA loaded, may be selected for hemodialysis applications. This may help to reduce the amount of heparin infused during hemodialysis, thereby reducing the side-effects associated with the systemic administration of heparin.|
|Education Level||UG and PG|
|Learning Resource Type||Article|
|Educational Framework||Medical Council of India (MCI)|
|Journal||JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION|
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