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Author Suboj, Priya ♦ Babykutty, Suboj ♦ Srinivas, P. ♦ Gopala, S.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Pharmacology
File Format PDF
Language English
Subject Domain (in DDC) Natural sciences & mathematics ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Technology ♦ Medicine & health
Subject Domain (in MeSH) Neoplasms ♦ Diseases ♦ Polycyclic Compounds ♦ Enzymes and Coenzymes ♦ Amino Acids, Peptides, and Proteins ♦ Chemicals and Drugs ♦ Cell Physiological Phenomena ♦ Biological Sciences
Subject Keyword Biochemistry
Abstract Aloe emodin (AE), a natural anthraquinone, is reported to have antiproliferative activity in various cancer cell lines. In this study, we analyzed the molecular mechanisms involved in the growth-inhibitory activity of this hydroxyanthraquinone in colon cancer cell, WiDr. In our observation AE inhibited cell proliferation by arresting the cell cycle at the G2/M phase and inhibiting cyclin B1. AE appreciably induced cell death specifically through the induction of apoptosis and by activating caspases 9/6. Apoptotic execution was found to be solely dependent on caspase-6 rather than caspase-3 or caspase-7. This is the first study indicating that the AE induces apoptosis specifically through the activation of caspase-6. Copyright (C) 2012 S. Karger AG, Basel
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Journal PHARMACOLOGY
Volume Number 89
Issue Number 40910
Page Count 8
Starting Page 91
Ending Page 98