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Author Jayabalan, M. ♦ Shunmugakumar, N.
Source Sree Chitra Tirunal Institute for Medical Sciences & Technology
Content type Text
Publisher Medical Progress Through Technology
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Domain (in MeSH) Immune System Phenomena ♦ Biological Sciences
Subject Keyword Biocompatibility
Abstract Shelf life and long-term environmental stability of polyurethanes intended for percutaneous applications and various biomedical applications are largely depend on their resistance to fungal attack and growth. Two classes of aliphatic crosslinked polyurethanes based on hexamethylene diisocyanate (HDI) and bicyclo-hexyl-methane diisocyanate (SM DI) were subjected to cell-free enzymatic degradation using hydrolytic and oxidative enzymes and to fungal attack and fungal growth using Aspergillus niger and Penicillium Sp. The present crosslinked polyurethanes are not susceptible to degradation by hydrolytic enzymes. The marginal loss of tensile strength in buffered solution of papain is attributed to plasticization by the absorbed components of the enzyme solution. The PEG based crosslinked polyurethanes are marginally susceptible to degradation by lactic dehydrogenase solution. The present polyurethanes are resistant to fungal attack. The fungal growth was not observed with PTMG and PPG based Polyurethanes, however, a marginal growth was observed with PEG based polyurethanes.
Education Level UG and PG
Learning Resource Type Article
Educational Framework Medical Council of India (MCI)
Volume Number 20
Issue Number 40972
Page Count 10
Starting Page 261
Ending Page 270