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Author Hoover, Lance R. ♦ Dinavahi, Radhika ♦ Cheng, Wei-Ping ♦ Cooper, John R. ♦ Marino, Maria Rosa ♦ Spata, Tyler C. ♦ Daniels, Gaile L. ♦ Vaughn, William K. ♦ Nussmeier, Nancy A.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Lippincott Williams & Wilkins
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Surgery & related medical specialties ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Cardiovascular System ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Nervous System Diseases ♦ Diseases ♦ Inorganic Chemicals ♦ Chemicals and Drugs ♦ Diagnosis ♦ Therapeutics ♦ Surgical Procedures, Operative ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Chemical Phenomena ♦ Physiological Phenomena ♦ Circulatory and Respiratory Physiological Phenomena ♦ Biological Sciences ♦ Persons ♦ Persons
Subject Keyword Discipline Anesthesiology ♦ Cardiac Surgical Procedures ♦ Cardiopulmonary Bypass ♦ Cerebrovascular Circulation ♦ Cerebrovascular Disorders ♦ Etiology ♦ Extracorporeal Membrane Oxygenation ♦ Hypothermia, Induced ♦ Jugular Veins ♦ Oxygen ♦ Blood ♦ Acid-base Equilibrium ♦ Aged ♦ Blood Gas Analysis ♦ Body Temperature ♦ Adverse Effects ♦ Physiopathology ♦ Prevention & Control ♦ Female ♦ Homeostasis ♦ Humans ♦ Hydrogen-ion Concentration ♦ Male ♦ Middle Aged ♦ Monitoring, Intraoperative ♦ Methods ♦ Prospective Studies ♦ Risk Assessment ♦ Comparative Study ♦ Journal Article ♦ Randomized Controlled Trial ♦ Research Support, Non-u.s. Gov't
Abstract In a prospective, randomized study of cardiac surgical patients at risk for impaired cerebral blood flow autoregulation, we compared alpha-stat and pH-stat blood gas management. The 40 patients enrolled had age >70 yr, diabetes, prior stroke, or uncontrolled hypertension. During hypothermia and early rewarming, jugular oxygen tensions were significantly lower in alpha-stat patients (n = 12) than pH-stat patients (n = 19; P < 0.05). During rewarming, jugular venous desaturation (i.e., SjvO(2) <50%) occurred in 6 of 12 alpha-stat patients, but no pH-stat patients (P = 0.0006). Patients at risk for poor cerebral autoregulation have higher oxygen tensions and saturations if pH-stat blood gas management is used during cardiopulmonary bypass.
Description Country affiliation: United States
Author Affiliation: Hoover LR ( Department of Cardiothoracic Anesthesia, San Antonio Uniform Health Education Consortium, San Antonio, Texas, USA.)
ISSN 00032999
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2009-05-01
Publisher Place United States
e-ISSN 15267598
Journal Anesthesia & Analgesia
Volume Number 108
Issue Number 5


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Source: WHO-Global Index Medicus