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Author Pizzichetta, M. A. ♦ Kittler, H. ♦ Stanganelli, I. ♦ Bono, R. ♦ Cavicchini, S. ♦ De Giorgi, V. ♦ Ghigliotti, G. ♦ Quaglino, P. ♦ Rubegni, P. ♦ Argenziano, G. ♦ Talamini, R.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley-Blackwell (on behalf of British Association of Dermatologists)
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Life sciences; biology ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Neoplasms ♦ Skin and Connective Tissue Diseases ♦ Diseases ♦ Diagnosis ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Persons ♦ Persons
Subject Keyword Discipline Dermatology ♦ Melanoma ♦ Pathology ♦ Skin Neoplasms ♦ Adolescent ♦ Adult ♦ Aged ♦ Aged, 80 And Over ♦ Carcinoma, Basal Cell ♦ Child ♦ Dermoscopy ♦ Diagnosis, Differential ♦ Female ♦ Humans ♦ Keratosis, Seborrheic ♦ Male ♦ Middle Aged ♦ Nevus, Pigmented ♦ Observer Variation ♦ Predictive Value Of Tests ♦ Retrospective Studies ♦ Young Adult ♦ Journal Article
Abstract BACKGROUND: Nodular melanoma (NM), representing 10-30% of all melanomas, plays a major role in global mortality related to melanoma. Nonetheless, the literature on dermoscopy of NM is scanty. OBJECTIVES: To assess odds ratios (ORs) to quantify dermoscopic features of pigmented NM vs. pigmented superficial spreading melanoma (SSM), and pigmented nodular nonmelanocytic and benign melanocytic lesions. METHODS: To assess the presence or absence of global patterns and dermoscopic criteria, digitized images of 457 pigmented skin lesions from patients with a histopathological diagnosis of NM (n = 75), SSM (n = 93), and nodular nonmelanocytic and benign melanocytic lesions (n = 289; namely, 39 basal cell carcinomas, 85 seborrhoeic keratoses, 81 blue naevi, and 84 compound/dermal naevi) were retrospectively collected and blindly evaluated by three observers. RESULTS: Multivariate analysis showed that ulceration (OR 4.07), homogeneous disorganized pattern (OR 10.76), and homogeneous blue pigmented structureless areas (OR 2.37) were significantly independent prognostic factors for NM vs. SSM. Multivariate analysis of dermoscopic features of NM vs. nonmelanocytic and benign melanocytic lesions showed that the positive correlating features leading to a significantly increased risk of NM were asymmetric pigmentation (OR 6.70), blue-black pigmented areas (OR 7.15), homogeneous disorganized pattern (OR 9.62), a combination of polymorphous vessels and milky-red globules/areas (OR 23.65), and polymorphous vessels combined with homogeneous red areas (OR 33.88). CONCLUSIONS: Dermoscopy may be helpful in improving the recognition of pigmented NM by revealing asymmetric pigmentation, blue-black pigmented areas, homogeneous disorganized pattern and abnormal vascular structures, including polymorphous vessels, milky-red globules/areas and homogeneous red areas.
Description Country affiliation: Italy
Author Affiliation: Pizzichetta MA ( Division of Medical Oncology - Preventive Oncology, Centro di Riferimento Oncologico, National Cancer Institute, Via Franco Gallini, 2, 33081, Aviano, Italy.); Kittler H ( Department of Dermatology, University of Vienna, Vienna, Austria.); Stanganelli I ( Skin Cancer Unit, Istituto Tumori Romagna (IRST), Meldola, Italy.); Bono R ( Istituto Dermopatico Immacolata, IRCCS, Rome, Italy.); Cavicchini S ( Department of Dermatology, Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy.); De Giorgi V ( Department of Dermatology, University of Florence, Florence, Italy.); Ghigliotti G ( Clinic of Dermatology, IRCCS San Martino - Ist, Genoa, Italy.); Quaglino P ( Dermatologic Clinic, Department of Medical Sciences, University of Turin, Turin, Italy.); Rubegni P ( Department of Dermatology, University of Siena, Siena, Italy.); Argenziano G ( Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy.); Talamini R ( Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, National Cancer Institute, Via Franco Gallini, 2, 33081, Aviano, Italy.)
ISSN 00070963
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2015-07-01
Publisher Place Great Britain (UK)
e-ISSN 13652133
Journal British Journal of Dermatology
Volume Number 173
Issue Number 1


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Source: WHO-Global Index Medicus