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Author Aouad, Marie T. ♦ Al-Alami, Achir A. ♦ Nasr, Viviane G. ♦ Souki, Fouad G. ♦ Zbeidy, Reine A. ♦ Siddik-Sayyid, Sahar M.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Lippincott Williams & Wilkins
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Body Regions ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Respiratory Tract Diseases ♦ Nervous System Diseases ♦ Cardiovascular Diseases ♦ Diseases ♦ Heterocyclic Compounds ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Diagnosis ♦ Therapeutics ♦ Anesthesia and Analgesia ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Physical Phenomena ♦ Biological Sciences ♦ Persons ♦ Persons
Subject Keyword Discipline Anesthesiology ♦ Analgesics, Opioid ♦ Administration & Dosage ♦ Anesthesia Recovery Period ♦ Anesthesia, General ♦ Intubation, Intratracheal ♦ Piperidines ♦ Adolescent ♦ Adult ♦ Blood Pressure ♦ Drug Effects ♦ Cough ♦ Etiology ♦ Prevention & Control ♦ Double-blind Method ♦ Drug Administration Schedule ♦ Female ♦ Heart Rate ♦ Humans ♦ Hypotension ♦ Infusions, Intravenous ♦ Adverse Effects ♦ Male ♦ Middle Aged ♦ Nose ♦ Surgery ♦ Prospective Studies ♦ Psychomotor Agitation ♦ Severity Of Illness Index ♦ Tachycardia ♦ Time Factors ♦ Treatment Outcome ♦ Young Adult ♦ Journal Article ♦ Randomized Controlled Trial ♦ Research Support, Non-u.s. Gov't
Abstract BACKGROUND: Emergence from general anesthesia can be associated with coughing, agitation, and hemodynamic disturbances. Remifentanil may attenuate these responses. METHODS: In a prospective, double-blind, randomized trial, we enrolled 60 adult patients undergoing nasal surgery using remifentanil-based anesthesia. During the emergence phase, the remifentanil group had remifentanil reduced to one tenth of the maintenance rate, whereas the control group had remifentanil discontinued. RESULTS: Times to awakening and tracheal extubation were similar between the two groups. During emergence, the remifentanil group (infusion rate 0.014 +/- 0.011 microg x kg(-1) x min(-1)) had a significantly lower incidence (40% vs 80%, P = 0.002) and less severe coughing compared with the control group, as well as a lower incidence of nonpurposeful movement (3.3% vs 30%, P = 0.006) and slower heart rates. CONCLUSIONS: Low-dose remifentanil during emergence did not prolong wake-up but reduced the incidence and severity of coughing from the endotracheal tube.
Description Country affiliation: Lebanon
Author Affiliation: Aouad MT ( Department of Anesthesiology, American University of Beirut Medical Center, Beirut, Lebanon.)
ISSN 00032999
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2009-04-01
Publisher Place United States
e-ISSN 15267598
Journal Anesthesia & Analgesia
Volume Number 108
Issue Number 4


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Source: WHO-Global Index Medicus