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Author Sheen, Michael J. ♦ Ho, Shung-Tai ♦ Lee, Chian-Her ♦ Tsung, Yu-Chi ♦ Chang, Fang-Lin
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Lippincott Williams & Wilkins
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Body Regions ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Skin and Connective Tissue Diseases ♦ Diseases ♦ Organic Chemicals ♦ Heterocyclic Compounds ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Diagnosis ♦ Therapeutics ♦ Anesthesia and Analgesia ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Physical Phenomena ♦ Biological Sciences ♦ Persons ♦ Persons
Subject Keyword Discipline Anesthesiology ♦ Amines ♦ Administration & Dosage ♦ Anesthesia, Spinal ♦ Antipruritics ♦ Cyclohexanecarboxylic Acids ♦ Morphine ♦ Adverse Effects ♦ Narcotics ♦ Orthopedic Procedures ♦ Premedication ♦ Pruritus ♦ Prevention & Control ♦ Gamma-aminobutyric Acid ♦ Adult ♦ Anesthetics, Local ♦ Bupivacaine ♦ Double-blind Method ♦ Drug Administration Schedule ♦ Female ♦ Humans ♦ Injections, Spinal ♦ Lower Extremity ♦ Surgery ♦ Male ♦ Prospective Studies ♦ Chemically Induced ♦ Severity Of Illness Index ♦ Time Factors ♦ Treatment Outcome ♦ Journal Article ♦ Randomized Controlled Trial ♦ Research Support, Non-u.s. Gov't
Abstract BACKGROUND: Pruritus is the most common side effect of intrathecal morphine. Gabapentin is an anticonvulsant and had been reported to be effective in some chronic pruritus conditions. Its effect in intrathecal morphine-induced pruritus has not yet undergone an evaluation. METHODS: We randomly allocated 86 patients scheduled for lower limb surgery under spinal anesthesia into two equal groups that received either gabapentin 1200 mg or placebo 2 h before operation in a prospective, double-blind manner. All patients received an intrathecal injection of 15 mg of 0.5% isobaric bupivacaine and 0.2 mg preservative-free morphine. Pruritus was evaluated at 3, 6, 9, 12, and 24 h after intrathecal morphine administration. RESULTS: The incidence of pruritus was significantly more frequent in the placebo group compared with the gabapentin group (77.5% vs 47.5%; P = 0.01). The onset time of pruritus in the gabapentin group (6.2 +/- 1.8 h) was significantly delayed compared with that in the placebo group (3.1 +/- 0.8 h) (P < 0.0001). The severity of pruritus was significantly more in the placebo group compared with the gabapentin group at 3 and 6 h after intrathecal morphine injection. CONCLUSION: Preoperative gabapentin prevents pruritus induced by intrathecal morphine in patients undergoing lower limb surgery with spinal anesthesia.
Description Country affiliation: Taiwan
Author Affiliation: Sheen MJ ( Department of Anesthesiology, Tri-Service General Hospital, 325, Chenggong Rd, Section 2, Nei-hu, Taipei, 11490, Taiwan. mkjsheen@mail.ndmctsgh.edu.t)
ISSN 00032999
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2008-06-01
Publisher Place United States
e-ISSN 15267598
Journal Anesthesia & Analgesia
Volume Number 106
Issue Number 6


Source: WHO-Global Index Medicus