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Author Ho, Jonathan K. ♦ Liakopoulos, Oliver J. ♦ Crowley, Ryan ♦ Yezbick, Aaron B. ♦ Sanchez, Elizabeth ♦ Shivkumar, Kalyanam ♦ Mahajan, Aman
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Lippincott Williams & Wilkins
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Surgery & related medical specialties ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Musculoskeletal System ♦ Cardiovascular System ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Cardiovascular Diseases ♦ Animal Diseases ♦ Diseases ♦ Inorganic Chemicals ♦ Chemicals and Drugs ♦ Diagnosis ♦ Surgical Procedures, Operative ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Physical Phenomena ♦ Circulatory and Respiratory Physiological Phenomena ♦ Biological Sciences
Subject Keyword Discipline Anesthesiology ♦ Myocardial Ischemia ♦ Diagnosis ♦ Myocardium ♦ Metabolism ♦ Oxygen ♦ Spectrum Analysis ♦ Animals ♦ Aorta ♦ Surgery ♦ Cardiopulmonary Bypass ♦ Adverse Effects ♦ Coronary Vessels ♦ Disease Models, Animal ♦ Echocardiography, Transesophageal ♦ Equipment Design ♦ Feasibility Studies ♦ Heart Arrest, Induced ♦ Hemodynamics ♦ Etiology ♦ Physiopathology ♦ Pathology ♦ Predictive Value Of Tests ♦ Pulmonary Artery ♦ Reproducibility Of Results ♦ Instrumentation ♦ Swine ♦ Time Factors ♦ Ventricular Dysfunction, Right ♦ Complications ♦ Journal Article ♦ Research Support, N.i.h., Extramural
Abstract BACKGROUND: Monitoring tissue oxygenation (StO(2)) by visible light spectroscopy (VLS) can identify tissue ischemia, but its feasibility for detecting myocardial ischemia is not known. We hypothesized that VLS can reliably detect changes in myocardial StO(2) in pigs subjected to acute regional or global myocardial ischemia. METHODS: In 11 pigs, regional myocardial ischemia was created by ligation of left anterior descending artery (LAD). Myocardial StO(2) was determined from the ischemic and nonischemic left ventricular (LV) regions and compared to coronary venous saturations. Myocardial function was assessed by echocardiography. In six pigs, LV-StO(2) was measured during cardiopulmonary bypass (CPB), after cardioplegic cardiac arrest, and during CPB with inadequate myocardial protection. Additionally, right ventricular (RV)- and LV-StO(2) were assessed during acute RV pressure overload from pulmonary artery (PA) banding. RESULTS: StO(2) baselines in pigs undergoing LAD occlusion were similar in the ischemic and nonischemic myocardium (70% +/- 8% vs 74% +/- 5%). After LAD ligation, StO(2) rapidly declined (30 s: 59% +/- 8%; 1 min:50 +/- 9; 5 min:42% +/- 4%; P < 0.05) in the ischemic myocardium. Decreases in StO(2) correlated with coronary venous saturations (r = 0.88) and were associated with myocardial dysfunction. In pigs undergoing CPB, LV-StO(2) remained unchanged with initiation of CPB or after cardioplegic cardiac arrest, but LV ischemia was detected by StO(2) after aortic cross-clamp without adequate myocardial protection. Similarly, PA banding resulted in a profound decrease of RV-StO(2) from 69% +/- 6% to 52% +/- 7% (P < 0.05) with recovery after PA release. CONCLUSIONS: VLS is a reliable method of detecting alterations in myocardial StO(2) and can be a useful monitor for rapid identification of myocardial ischemia.
Description Country affiliation: United States
Author Affiliation: Ho JK ( Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.)
ISSN 00032999
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2009-04-01
Publisher Place United States
e-ISSN 15267598
Journal Anesthesia & Analgesia
Volume Number 108
Issue Number 4


Source: WHO-Global Index Medicus