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Author Shih, Chao-Ming ♦ Cheng, Shin-Nan ♦ Wong, Chih-Shung ♦ Kuo, Yu-Ling ♦ Chou, Tz-Chong
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Lippincott Williams & Wilkins
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Philosophy & psychology ♦ Psychology ♦ Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human physiology ♦ Incidence & prevention of disease ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Nervous System Diseases ♦ Animal Diseases ♦ Pathological Conditions, Signs and Symptoms ♦ Diseases ♦ Inorganic Chemicals ♦ Macromolecular Substances ♦ Enzymes and Coenzymes ♦ Carbohydrates ♦ Lipids ♦ Amino Acids, Peptides, and Proteins ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Diagnosis ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Psychological Phenomena and Processes ♦ Psychiatry and Psychology ♦ Physical Phenomena ♦ Physiological Phenomena ♦ Immune System Phenomena ♦ Biological Sciences
Subject Keyword Discipline Anesthesiology ♦ Analgesics ♦ Pharmacology ♦ Anti-inflammatory Agents ♦ Hyperalgesia ♦ Prevention & Control ♦ Inflammation ♦ Phycocyanin ♦ Animals ♦ Carrageenan ♦ Cyclooxygenase 2 ♦ Metabolism ♦ Dinoprostone ♦ Disease Models, Animal ♦ Dose-response Relationship, Drug ♦ Hot Temperature ♦ Etiology ♦ Chemically Induced ♦ Interleukin-10 ♦ Male ♦ Neutrophil Infiltration ♦ Drug Effects ♦ Nitrates ♦ Nitric Oxide Synthase Type Ii ♦ Pain Measurement ♦ Pain Threshold ♦ Peroxidase ♦ Rats ♦ Rats, Sprague-dawley ♦ Reaction Time ♦ Time Factors ♦ Tumor Necrosis Factor-alpha ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract BACKGROUND: C-phycocyanin (C-PC), a biliprotein found in blue green algae, such as Spirulina platensis, is often used as a dietary nutritional supplement due to its various therapeutic values. In addition, the antiinflammatory activity of C-PC partly through inhibition of proinflammatory cytokine formation, inducible nitric oxide synthase (iNOS) and cyclooxygeanase-2 (COX-2) expression has been demonstrated in many in vitro and in vivo studies. However, whether C-PC also has antihyperalgesic activity in inflammatory nociception has not been investigated. METHODS: Using a carrageenan-induced thermal hyperalgesia model, we evaluated the effect of C-PC on nociception by measuring paw withdrawal latency. To clarify the mechanisms involved, the expression of iNOS and COX-2 and the formation of nitrate and tumor necrosis factor-alpha (TNF-alpha) in the rat paw were determined. RESULTS: Pre- or posttreatment with C-PC (30 or 50 mg/kg, IP) significantly attenuated carrageenan-induced inflammatory nociception and the induction of iNOS and COX-2 at the late phase, (4 h) accompanied by an inhibition of the formation of TNF-alpha, prostaglandin E(2), nitrate and myeloperoxidase activity. CONCLUSIONS: Based on these results, it is suggested that the inhibition of NO and prostaglandin E(2) over-production through suppressing iNOS and COX-2 induction and attenuation of TNF-alpha formation and neutrophil infiltration into inflammatory sites by C-PC may contribute, at least in part, to its antihyperalgesic activity.
Description Country affiliation: China
Author Affiliation: Shih CM ( Chia-Yi Christian Hospital, Taipei, Taiwan, Republic of China.)
ISSN 00032999
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2009-04-01
Publisher Place United States
e-ISSN 15267598
Journal Anesthesia & Analgesia
Volume Number 108
Issue Number 4

Source: WHO-Global Index Medicus