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Author Iinuma, Hironobu ♦ Matsuzaki, Meiki ♦ Nagatsu, Toshiharu ♦ Takeuchi, Tomio ♦ Umezawa, Hamao
Source J-STAGE
Content type Text
Publisher Japan Society for Bioscience, Biotechnology, and Agrochemistry
Language English
Abstract Dopastin produced by a pseudomonas is a potent inhibitor of dopamine β-hydroxylase. Kinetic studies with the purified enzyme indicated that inhibition by dopastin was of the uncompetitive type to the substrate and of the competitive to the cofactor, ascorbic acid. The nitrosohydroxylamino group of dopastin was found to be essential in inhibition of dopamine β-hydroxylase. Both racemic and natural dopastins showed the same activity. Dopastin showed significant hypotensive effect to spontaneously hypertensive rats and phytotoxicity to barley germination.
ISSN 00021369
Learning Resource Type Article
Publisher Date 1974-01-01
e-ISSN 18811280
Journal Agricultural and Biological Chemistry(bbb1961)
Volume Number 38
Issue Number 11
Page Count 5
Starting Page 2107
Ending Page 2111


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