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Author Isono, Kiyoshi ♦ Suzuki, Saburo ♦ Tanaka, Michio ♦ Nanbata, Takeo ♦ Shibuya, Kunitoyo
Source J-STAGE
Content type Text
Publisher Japan Society for Bioscience, Biotechnology, and Agrochemistry
Language English
Abstract 5-Carboxyuracil derivatives were shown to react with aqueous sodium bisulfite in mild condition resulting in facile decarboxylation to give corresponding 5-decarboxy-5, 6-dihydrouracil-6-sulfonates and uracils in good yield. The former compounds were quantitatively transformed to the latter in alkaline condition. Mechanistic feature of this reaction was discussed, which implied the initial nucleophilic addition of bisulfite across the 5, 6-double bond. 5-Carboxycytosine was also shown to react similarly, however, accompanied by hydrolytic deamination.
ISSN 00021369
Learning Resource Type Article
Publisher Date 1972-01-01
e-ISSN 18811280
Journal Agricultural and Biological Chemistry(bbb1961)
Volume Number 36
Issue Number 9
Page Count 9
Starting Page 1571
Ending Page 1579


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