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Author Ito, Teiichiro ♦ Ishii, Tadao
Source J-STAGE
Content type Text
Publisher Japan Society for Bioscience, Biotechnology, and Agrochemistry
Language English
Abstract The structure-activity in α-alkylthio-cinnamyl penicillins was studied. These penicillins were prepared by condensing 6-aminopenicillanic acid with α-alkylthio-cinnamic acids. α-Methylthio-cinnamyl penicillin and its substituted analogues were highly inhibitory to Staphylococcus aureus 209P and some of them were also effective in vitro against benzyl-penicillin-resistant Staphylococci. trans-α-Methylthio-2-bromo-cinnamyl penicillin, which showed a good in vitro activity, was resistant to penicillinase and was stable in acidic aqueous solution.
ISSN 00021369
Learning Resource Type Article
Publisher Date 1966-01-01
e-ISSN 18811280
Journal Agricultural and Biological Chemistry(bbb1961)
Volume Number 30
Issue Number 10
Page Count 7
Starting Page 1047
Ending Page 1053


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