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Author Heidari, Reza ♦ Ommati, Mohammad Mehdi ♦ Niknahad, Hossein ♦ Ghanbarinejad, Vahid ♦ Jamshidzadeh, Akram
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Shiraz University of Medical Sciences
File Format HTM / HTML
Date Created 2018-08-06
Copyright Year ©2018
Language English
Subject Domain (in LCC) RS1-441
Subject Keyword Medicine ♦ Pharmacy and materia medica
Abstract Carnosine is an abundantly found dipeptide present in different tissues. Several pharmacological properties have been attributed to carnosine. On the other hand, the precise mechanism of cytoprotection provided by carnosine remains obscure. The current study aimed to evaluate the direct effect of different concentrations of carnosine on cellular mitochondria as an essential target involved in the cytoprotection/cytotoxicity. Liver mitochondria were isolated and exposed to carnosine (0.01-20 mM). Mitochondrial depolarization, dehydrogenases activity, mitochondrial swelling and permeability, and ATP content were assessed. On the other hand, the effect of carnosine supplementation on calcium (Ca <sup>2+</sup>) overload-induced mitochondrial injury was evaluated. It was found that concentrations between 0.01-20 mM of this peptide preserved mitochondrial indices of functionality in a Ca <sup>2+ </sup>overloaded environment. These data represent regulation of mitochondrial function as a primary mechanism for the protective properties of carnosine.
ISSN 24235652
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2018-03-01
e-ISSN 24235652
Journal Trends in Pharmaceutical Sciences
Volume Number 4
Issue Number 1

Source: Directory of Open Access Journals (DOAJ)