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Author Sathyanarayanan, Anusha ♦ Chandrasekaran, Karthik Subramanian ♦ Karunagaran, Devarajan
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ INHIBITION ♦ MIGRATION ♦ NEOPLASMS ♦ PLANT GROWTH
Abstract microRNAs (miRNAs) play significant roles in diverse biological processes and their deregulation is implicated in carcinogenesis. miR-146a executes tumour suppressive or oncogenic functions depending on the cancer type, but its effect on human cervical (CaCx) and colorectal (CRC) cancers have not been examined thus far. In this study, miR-146a exhibited high expression in CaCx but poor expression in CRC, in comparison to corresponding normal tissues. Nevertheless, ectopic expression of miR-146a inhibited proliferation in both CaCx and CRC cells and curbed their migration and invasion. When the expression of endogenous miR-146a was suppressed, proliferative, migratory and invasive capacities of CaCx and CRC cells increased, suggesting an anti-tumourigenic function for miR-146a. Re-expression of miR-146a down-regulated the expression of crucial signalling intermediates: CTNNB1, STAT3, RELA, CCND1 and SNAI1, and enhanced TP53 and CDH1 expression. Thus, the present study reveals a hitherto unknown tumour suppressive role for miR-146a providing a plausible mechanistic basis for it. - Highlights: • miR-146a inhibits proliferation in human cervical and colorectal cancer cells. • miR-146a retards migratory and invasive potentials of cancer cells. • AntimiR-146a enhances growth and motility. • miR-146a modulates the expression of a few genes related to growth and motility. • miR-146a is highly expressed in cervical but poorly so in colorectal tumours.
ISSN 0006291X
Educational Use Research
Learning Resource Type Article
Publisher Date 2016-11-25
Publisher Place United States
Journal Biochemical and Biophysical Research Communications
Volume Number 480
Issue Number 4


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