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Author Qian, Yu ♦ Xia, Suhua ♦ Feng, Zhenyu
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ ANIMAL TISSUES ♦ CELL PROLIFERATION ♦ NEOPLASMS ♦ PLANT GROWTH ♦ PLANT TISSUES ♦ PROMOTERS
Abstract FOXK2, which belongs to the fork head DNA binding protein family, has been shown to play a critical role in tumorigenesis. Here, we detected FOXK2 expression and its clinical significance in colorectal cancer, which has not been fully investigated before. Results from public database and our cohort indicated that FOXK2 was transcriptionally activated in colorectal cancer tissues compared to non-cancer tissues. High expression of FOXK2 was significantly correlated with poor survival. In vitro cell experiments suggested that FOXK2 promoted cell proliferation. Furthermore, we found that oncogene SOX9 was responsible for the up-regulation of FOXK2 by directly binding on its promoter. Depletion of FOXK2 attenuated SOX9 induced cell growth. In addition, we observed that the expression of FOXK2 was significantly associated with the expression of SOX9 both in the public database and our colorectal cancer tissues. The patients with SOX9{sup +}FOXK2{sup +} had a poor overall survival (p = 0.0084). In conclusion, our data suggested that SOX9 transcriptionally activated FOXK2 was involved in the pathogenesis of colorectal cancer and might be a novel target for colorectal cancer therapy. - Highlights: • FOXK2 is up-regulated in colorectal cancer and associated with poor prognosis. • FOXK2 promotes proliferation of CRC cells. • FOXK2 is transcriptional activated by SOX9. • FOXK2 expression is correlated with SOX9 in CRC tissues.
ISSN 0006291X
Educational Use Research
Learning Resource Type Article
Publisher Date 2017-01-29
Publisher Place United States
Journal Biochemical and Biophysical Research Communications
Volume Number 483
Issue Number 1


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