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Author Kwon, Hyukwoo ♦ Shin, Junghae ♦ Park, Hwajin ♦ Cho, Hyunjeong
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Elsevier
File Format HTM / HTML
Date Created 2017-03-15
Copyright Year ©2016
Language English
Subject Domain (in LCC) QK1-989
Subject Keyword VASP (Ser157) ♦ Fibrinogen binding ♦ Science ♦ Botany ♦ Clot retraction ♦ Ginsenoside Ro ♦ CAMP
Abstract Background: Glycoprotein IIb/IIIa (αIIb/β3) is involved in platelet adhesion, and triggers a series of intracellular signaling cascades, leading to platelet shape change, granule secretion, and clot retraction. In this study, we evaluated the effect of ginsenoside Ro (G-Ro) on the binding of fibrinogen to αIIb/β3. Methods: We investigated the effect of G-Ro on regulation of signaling molecules affecting the binding of fibrinogen to αIIb/β3, and its final reaction, clot retraction. Results: We found that G-Ro dose-dependently inhibited thrombin-induced platelet aggregation and attenuated the binding of fibrinogen to αIIb/β3 by phosphorylating cyclic adenosine monophosphate (cAMP)-dependently vasodilator-stimulated phosphoprotein (VASP; Ser157). In addition, G-Ro strongly abrogated the clot retraction reflecting the intensification of thrombus. Conclusion: We demonstrate that G-Ro is a beneficial novel compound inhibiting αIIb/β3-mediated fibrinogen binding, and may prevent platelet aggregation-mediated thrombotic disease.
ISSN 12268453
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2016-10-01
e-ISSN 12268453
Journal Journal of Ginseng Research
Volume Number 40
Issue Number 4
Page Count 7
Starting Page 359
Ending Page 365

Source: Directory of Open Access Journals (DOAJ)