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Author Forbes, D. P. ♦ Al-Bareedi, S.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword BASIC BIOLOGICAL SCIENCES ♦ CARTILAGE ♦ INHIBITION ♦ SKELETON ♦ MORPHOLOGICAL CHANGES ♦ AGE DEPENDENCE ♦ AUTORADIOGRAPHY ♦ FACE ♦ RATS ♦ SULFATES ♦ SULFUR 35 ♦ TEETH ♦ ANIMAL TISSUES ♦ ANIMALS ♦ BETA DECAY RADIOISOTOPES ♦ BETA-MINUS DECAY RADIOISOTOPES ♦ BODY ♦ BODY AREAS ♦ CONNECTIVE TISSUE ♦ DAYS LIVING RADIOISOTOPES ♦ DIGESTIVE SYSTEM ♦ EVEN-ODD NUCLEI ♦ HEAD ♦ ISOTOPES ♦ LIGHT NUCLEI ♦ MAMMALS ♦ NUCLEI ♦ ORAL CAVITY ♦ ORGANS ♦ OXYGEN COMPOUNDS ♦ RADIOISOTOPES ♦ RODENTS ♦ SULFUR COMPOUNDS ♦ SULFUR ISOTOPES ♦ TISSUES ♦ VERTEBRATES 550801* -- Morphology-- Tracer Techniques
Abstract A single craniofacial suture can undergo several morphologic transformations during its development. From 3 to 7 weeks of age, the intermaxillary suture of the rat is synchondrotic in character, featuring secondary cartilage; at later times, this suture is syndesmotic in character, featuring a fibrous tissue interface. Since intermittent mechanical stimulation has been reported to initiate secondary cartilage formation, a study was done to determine if the functioning dentition were responsible for secondary cartilage formation in the intermaxillary suture of the rat. Twenty-two female Sprague-Dawley rats were used. At 3 weeks of age, prior to eruption, the maxillary molars were enucleated from nine animals. Body weights were recorded weekly. Animals were sacrificed weekly from 4 to 7 weeks of age. One hour prior to sacrifice, each rat was injected with (/sup 35/S)sulfate at a dosage of 2 microCi/g body weight. The tissues were evaluated by light microscopy and autoradiography. In the experimental group, the midpalatal suture did not undergo the normal synchondrotic transformation. Instead, this suture remained fibrous with negligible metachromatic staining. In the control animals, the peak period of (/sup 35/S)sulfate incorporation was 4 weeks of age and was five times greater than in the experimental group. The primary stimulus for the initiation of secondary cartilage formation in the midpalatal suture of the rat was molar function. Also, functioning molars were found to be important in the maintenance of the palatal bone.
Educational Use Research
Learning Resource Type Article
Publisher Date 1986-01-01
Publisher Place United States
Journal J. Craniofacial Genet. Dev. Biol.
Volume Number 1
Organization Northwestern Univ. Dental School, Chicago, IL


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