|Author||Laha, Dipranjan ♦ Pramanik, Arindam ♦ Laskar, Aparna ♦ Jana, Madhurya ♦ Pramanik, Panchanan ♦ Karmakar, Parimal|
|Source||United States Department of Energy Office of Scientific and Technical Information|
|Subject Keyword||MATERIALS SCIENCE ♦ ATOMIC FORCE MICROSCOPY ♦ BACTERIA ♦ COPPER OXIDES ♦ DNA ♦ DNA DAMAGES ♦ FOURIER TRANSFORMATION ♦ INFRARED SPECTRA ♦ LIGHT SCATTERING ♦ MEMBRANES ♦ NANOPARTICLES ♦ SCANNING ELECTRON MICROSCOPY ♦ SPHERICAL CONFIGURATION ♦ STRAINS ♦ SYNTHESIS ♦ TRANSMISSION ELECTRON MICROSCOPY ♦ X-RAY DIFFRACTION|
|Abstract||Highlights: • Spherical and sheet shaped copper oxide nanoparticles were synthesized. • Physical characterizations of these nanoparticles were done by TEM, DLS, XRD, FTIR. • They showed shape dependent antibacterial activity on different bacterial strain. • They induced both membrane damage and ROS mediated DNA damage in bacteria. - Abstract: In this work, we synthesized spherical and sheet shaped copper oxide nanoparticles and their physical characterizations were done by the X-ray diffraction, fourier transform infrared spectroscopy, transmission electron microscopy and dynamic light scattering. The antibacterial activity of these nanoparticles was determined on both gram positive and gram negative bacterial. Spherical shaped copper oxide nanoparticles showed more antibacterial property on gram positive bacteria where as sheet shaped copper oxide nanoparticles are more active on gram negative bacteria. We also demonstrated that copper oxide nanoparticles produced reactive oxygen species in both gram negative and gram positive bacteria. Furthermore, they induced membrane damage as determined by atomic force microscopy and scanning electron microscopy. Thus production of and membrane damage are major mechanisms of the bactericidal activity of these copper oxide nanoparticles. Finally it was concluded that antibacterial activity of nanoparticles depend on physicochemical properties of copper oxide nanoparticles and bacterial strain.|
|Learning Resource Type||Article|
|Publisher Place||United States|
|Journal||Materials Research Bulletin|
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