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Author Hardisty, R. M. ♦ McElwain, T. J. ♦ Darby, Caryl W.
Source British Medical Journal (The BMJ)
Content type Text
Publisher British Medical Journal Publishing Group
File Format HTM / HTML
Language English
Abstract A total of 65 children with acute lymphoblastic leukaemia and seven with other types of acute leukaemia received treatment with a combination of vincristine and prednisone. In all 122 courses of treatment were given. Of 22 patients with acute lymphoblastic leukaemia who received this as their first treatment, all achieved complete remission. The complete remission rates were 82% for patients with acute lymphoblastic leukaemia in their first relapse, 63% in the second relapse, and much lower in subsequent relapses and in the patients with other types of acute leukaemia. Alopecia and gastrointestinal and neuromuscular toxicity occurred respectively in 51%, 29%, and 21% of instances, only the last of these side-effects of vincristine being dose-related. Most of the complete remissions were obtained with a total dose of vincristine which carried only a low risk of neurotoxicity.
Description Citation Reference: British Medical Journal
ISSN 00071447
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Learning Resource Type Article
Publisher Date 1969-06-14
e-ISSN 14685833
Journal British Medical Journal (The BMJ)
Volume Number 2
Issue Number 5658
Page Count 4
Starting Page 662
Ending Page 665


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Source: British Medical Journal (The BMJ)