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Author Voloshin, Tali ♦ Fremder, Ella ♦ Shaked, Yuval
Source SpringerLink
Content type Text
Publisher Springer Netherlands
File Format PDF
Copyright Year ©2014
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Biomarkers ♦ Metastasis ♦ Angiogenesis ♦ Cancer therapy ♦ Bone marrow derived cells ♦ Tumor microenvironment ♦ Cancer Research ♦ Oncology ♦ Immunology ♦ Cell Biology ♦ Biochemistry ♦ Biomedicine general
Abstract A wide spectrum of both normal and diseased cell types shed extracellular vesicles that facilitate intercellular communication without direct cell-to-cell contact. Microparticles (MPs) are a subtype of extracellular vesicles that participate in multiple biological processes. They carry abundant bioactive molecules including different forms of nucleic acids and proteins that can markedly modulate cellular behavior. MPs are involved in several hallmarks of cancer such as drug resistance, thrombosis, immune evasion, angiogenesis, tumor invasion and metastasis. Such MPs originate from either cancer or other host cells. As MPs are secreted and can be detected in various body fluids, they can be used as potential diagnostic and prognostic biomarkers as well as vehicles for delivery of cytotoxic drugs. This review summarizes accumulating evidence on the biological properties of MPs in cancer, with reference to their potential usage in clinical settings.
ISSN 18752292
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-04-06
Publisher Institution International Cancer Microenvironment Society
Publisher Place Dordrecht
e-ISSN 18752284
Journal Cancer Microenvironment
Volume Number 7
Issue Number 1-2
Page Count 11
Starting Page 11
Ending Page 21


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Source: SpringerLink