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Author Augsten, Martin ♦ Hägglöf, Christina ♦ Peña, Cristina ♦ Östman, Arne
Source SpringerLink
Content type Text
Publisher Springer Netherlands
File Format PDF
Copyright Year ©2010
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Tumor microenvironment ♦ Tumor stroma ♦ Therapy ♦ Biomedicine general ♦ Biochemistry ♦ Cell Biology ♦ Immunology ♦ Oncology ♦ Cancer Research
Abstract Experimental studies and analyses of clinical material have convincingly demonstrated that tumor formation and progression occurs through a concerted action of malignant cells and the surrounding microenvironment of the tumor stroma. The tumor microenvironment is comprised of various cell types like fibroblasts, immune cells, vascular cells and bone-marrow-derived cells embedded in the extracellular matrix. This review, focusing on recent findings in the context of gastrointestinal tumors, introduces the different stromal cell types and delineates their contributions to cancer initiation, growth and metastasis. By selected examples we also present how the tumor microenvironment is emerging as a promising target for therapeutic intervention.
ISSN 18752292
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2010-03-07
Publisher Institution International Cancer Microenvironment Society
Publisher Place Dordrecht
e-ISSN 18752284
Journal Cancer Microenvironment
Volume Number 3
Issue Number 1
Page Count 10
Starting Page 167
Ending Page 176


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Source: SpringerLink