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Author De Vico Fallani, Fabrizio ♦ Clausi, Silvia ♦ Leggio, Maria ♦ Chavez, Mario ♦ Valencia, Miguel ♦ Maglione, Anton Giulio ♦ Babiloni, Fabio ♦ Cincotti, Febo ♦ Mattia, Donatella ♦ Molinari, Marco
Source SpringerLink
Content type Text
Publisher Springer US
File Format PDF
Copyright Year ©2016
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Graph theory ♦ Cerebellum ♦ EEG ♦ Functional connectivity ♦ Brain plasticity ♦ Neurosciences ♦ Neurology ♦ Neurobiology
Abstract Although cerebellar-cortical interactions have been studied extensively in animal models and humans using modern neuroimaging techniques, the effects of cerebellar stroke and focal lesions on cerebral cortical processing remain unknown. In the present study, we analyzed the large-scale functional connectivity at the cortical level by combining high-density electroencephalography (EEG) and source imaging techniques to evaluate and quantify the compensatory reorganization of brain networks after cerebellar damage. The experimental protocol comprised a repetitive finger extension task by 10 patients with unilateral focal cerebellar lesions and 10 matched healthy controls. A graph theoretical approach was used to investigate the functional reorganization of cortical networks. Our patients, compared with controls, exhibited significant differences at global and local topological level of their brain networks. An abnormal rise in small-world network efficiency was observed in the gamma band (30–40 Hz) during execution of the task, paralleled by increased long-range connectivity between cortical hemispheres. Our findings show that a pervasive reorganization of the brain network is associated with cerebellar focal damage and support the idea that the cerebellum boosts or refines cortical functions. Clinically, these results suggest that cortical changes after cerebellar damage are achieved through an increase in the interactions between remote cortical areas and that rehabilitation should aim to reshape functional activation patterns. Future studies should determine whether these hypotheses are limited to motor tasks or if they also apply to cerebro-cerebellar dysfunction in general.
ISSN 14734222
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2016-07-02
Publisher Place New York
e-ISSN 14734230
Journal The Cerebellum
Volume Number 16
Issue Number 2
Page Count 18
Starting Page 358
Ending Page 375

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Source: SpringerLink